| Identification | Back Directory | [Name]
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) | [CAS]
69698-54-0 | [Synonyms]
vip 6-28
Aviptadil (6-28)
VIP (6-28) (huMan, Mouse, rat)
M.W. 2816.31 C126H207N37O34S
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT)
VIP (6-28) (HUMAN, RAT, PORCINE, BOVINE)
VIP(6-28)(HUMAN, RAT, PORCINE, BOVINE)?, >98%
vasoactive intestinal peptide*fragment 6-28 porci
6-28-Vasoactive intestinal octacosapeptide (swine)
VASOACTIVE INTESTINAL PEPTIDE FRAGMENT 6-28 PORCINE
VASOACTIVE INTESTINAL PEPTIDE (6-28), HUMAN, PORCINE, RAT
vasoactive intestinal peptide fragment 6-28 human, porcine, rat
VASOACTIVE INTESTINAL PEPTIDE (6-28) (HUMAN, BOVINE, PORCINE, RAT)
VIP(6-28)(human, rat, porcine, bovine),FTDNYTRLRKQMAVKKYLNSILN?, >98%
PHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2
H-PHE-THR-ASP-ASN-TYR-THR-ARG-LEU-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ASN-SER-ILE-LEU-ASN-NH2 | [Molecular Formula]
C126H207N37O34S | [MDL Number]
MFCD00237319 | [MOL File]
69698-54-0.mol | [Molecular Weight]
2816.28 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
H-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2 |
| Hazard Information | Back Directory | [Uses]
VIP(6-28)(human, rat, porcine, bovine) is an effective antagonist of the actions of exogenous vasoactive intestinal peptide (VIP) on cAMP. | [Biological Activity]
VIP(6-28)(human, rat, porcine, bovine) is a potent exogenous vasoactive intestinal peptide (VIP) antagonist. | [in vitro]
VIP (6-28) (HUMAN, BOVINE, PORCINE, RAT) is an effective VIP antagonist in the superior cervical ganglion (SCG) , and results obtained using this analog indicate that endogenous VIP can participate in a positive feedback loop in injured sympathetic neurons in which it enhances its own expression. VIP(6-28), when added to short-term cultures of adult SCG at a concentration of 10, 30, or 100 μM, reduces the increase in cAMP levels produced by stimulation with 10 μM VIP by 52, 64, or 81%, respectively. At any of these concentrations tested, VIP(6-28) by itself does not alter cAMP levels. In contrast to its ability to reduce the VIP-stimulated elevation in cAMP levels by 64%, the addition of 30 μM VIP(6-28) to culture medium does not significantly alter cAMP levels measured after stimulation of adult ganglia with either isoproterenol or forskolin (10 μM each). Similar results on the ability of VIP(6-28) to block VIP -stimulated increases in cAMP levels are obtained in neuron-enriched and in non-neuronal cell-en riched dissociated cultures. | [target]
| [References]
[1] Mohney RP, et al. Vasoactive intestinal peptide enhances its own expression in sympathetic neurons after injury. J Neurosci. 1998 Jul 15;18(14):5285-93. DOI:10.1523/JNEUROSCI.18-14-05285.1998 |
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