| Identification | More | [Name]
Sulbactam sodium | [CAS]
69388-84-7 | [Synonyms]
sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
SODIUM SULBACTAM
SULBACTAM SODIUM
SULBACTAM SODIUM SALT
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-7-oxo-,4,4-d
cp45899sodiumsalt
penicillanicacid1,1-dioxidesodiumsalt
penicillanicaciddioxidesodiumsalt
penicillanicacidsulfonesodiumsalt
sodium1,1-dioxopenicillanate
sodiumpenicillanate1,1-dioxide
sodiumsalt,(2s-cis)-ioxid
(2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]heptane-2-carboxylic acid 4,4-dioxide sodium salt
Sulbatam Sodium
sulbacyam sodium
AMPICILLIN SODIUM AND SULBACTAM SODIUM 2:1
CP-45899-2
Penicillanic acid 4,4-dioxide sodium salt | [EINECS(EC#)]
273-984-4 | [Molecular Formula]
C8H10NNaO5S | [MDL Number]
MFCD01750374 | [Molecular Weight]
255.22 | [MOL File]
69388-84-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
>230°C (dec.) | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
Freely soluble in water, sparingly soluble in ethyl acetate, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute acids. | [form ]
neat | [color ]
White | [InChIKey]
NKZMPZCWBSWAOX-IBTYICNHSA-M | [CAS DataBase Reference]
69388-84-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S22:Do not breathe dust .
S24:Avoid contact with skin .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [HS Code ]
29349990 | [Toxicity]
LD50 ivn-rat: 6500 mg/kg NKRZAZ 32(Suppl 4),97,84 |
| Hazard Information | Back Directory | [Description]
Sulbactam sodium is a parenterally-active, β-lactamase inhibitor recently
introduced as a 1: 1 combination product with cefoperazone. Like clavulanic acid,
the first agent of this type to b e introduced, sulbactam enhances the effectiveness
of β-lactam antibiotics against resistant strains. | [Chemical Properties]
White Solid | [Originator]
Pfizer (USA) | [Uses]
A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial. | [Definition]
ChEBI:Sulbactam sodium is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid. | [Manufacturing Process]
Sulbactam sodium is semi-synthetic antibiotic of penicillinic group. Start
material for it's synthesis is 6-aminopenicillanic acid. First 6-aminopenicillanic
acid was isolated in 1957 year from benzylpenicilline as resalt of treating of it
by penicillinaze. Benzylpenicilline is produced by microorganism of genus
Streptomyces.
Further, 6-aminopenicillanic acid reacted with bromine, hydrochloric acid and
NaNO2. As a result the 6,6-dibromopenicillanic acid was obtained.
6,6-Dibromopenicillanic acid was oxidized by KMnO4, to give 6,6-dibromo-1,1-The 6,6-dibromo-1,1-dioxopenicillanic acid in presence of Fe was converted to
the 1,1-dioxopenicillanic acid (sulbactam acid). The sulbactam acid was
treated by sodium 2-ethylhexanoate and crude sulbactam sodium was
obtained. | [Brand name]
SULPERAZONE | [Therapeutic Function]
Beta-lactamase inhibitor | [General Description]
Sulbactam was synthesized by Pfizer Research Laboratories in 1977 in the course of screening for β-lactamase inhibitors. It shows strong activity against penicillinase and moderate activity against cephalosporinase. Sulbactam itself shows activity against some gramnegative bacteria but no activity against most pathogenic bacteria. The use of sulbactam in combination with cefoperazone, which is partially hydrolyzed by penicillinase, is under study along with its use as an esterified complex with ampicillin (sultamicillin) for therapy of cefoperazone-ampicillin-resistant infections. | [Safety Profile]
Poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx | [storage]
Store at -20°C, protect from light, stored under nitrogen |
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