Identification | Back Directory | [Name]
BUSERELIN | [CAS]
68630-75-1 | [Synonyms]
Fuset hoe766 EstoMal Itorelin Suprecur hoe766mp SupreMon Buserecur Suprafact Suprecur-MP buserelinacetate BUSERELIN USP/EP/BP Buserelina(acetate) Buserelin Acetate, >99% Buserelin?Acetate impurity Buserelin acetate, Ph. Eur. Buserelin acetate [USAN:JAN] Buserelin Acetate, Buserelina Buserelin for NMR identification Buserelin for peak identification Buserelin for NMR identification CRS Buserelin for peak identification CRS (DES-GLY10,D-SER(TBU)6,PRO-NHET9)-LHRH des-gly10-[d-ser[t-bu]6]-lh-rh ethylamide PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET P-GLU-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-NHET 9-(n-ethyl-l-prolinamide)-10-deglycinamide,monoacetate(salt) 6-(o-(1,1-dimethylethyl)-d-serine)-luteinizinghormone-releasingfactor(pig pGlu-His-Trp-Ser-Tyr-D-Ser(t-Bu)-Leu-Arg-Pro-NHEt, des-Gly10-[D-Ser[t-Bu]6]-LH-RH ethylamide 6-[O-(1,1-DiMethylethyl)-D-serine]-9-(N-ethyl-L-prolinaMide)-1-9-luteinizing HorMone-releasing Factor Monoacetate 1-9-Luteinizing hormone-releasing factor (swine), 6-O-(1,1-dimethylethyl)-D-serine-9-(N-ethyl-L-prolinamide)-, monoacetate (salt) | [EINECS(EC#)]
636-185-5 | [Molecular Formula]
C62H90N16O15 | [MDL Number]
MFCD01716229 | [MOL File]
68630-75-1.mol | [Molecular Weight]
1299.5 |
Chemical Properties | Back Directory | [Melting point ]
186-188°C | [storage temp. ]
-20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic |
Hazard Information | Back Directory | [Description]
Buserelin acetate is a potent analog of the hypothalamic hormone, luteinizing
hormone-releasing hormone (LH-RH). Chronic administration of higher doses of
buserelin desensitizes the pituitary, resulting in a decreased production of
luteinizing hormone (LH), follicle stimulating hormone (FSH), and eventually
sex steroids (testosterone in males and estradiol in females). Initial approval is
for use in achieving medical castration in the treatment of advanced prostate
cancer. It has also been investigated for the treatment of endometriosis,
leiomyoma, precocious puberty, advanced breast cancer and infertility. | [Chemical Properties]
White Solid | [Originator]
Hoechst AG (W. Germany) | [Uses]
Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal). | [Definition]
ChEBI: Buserelin acetate is an organic molecular entity. | [Brand name]
Suprefact
(Hoechst-Roussel). | [Biochem/physiol Actions]
Buserelin is an LH-RH agonist. |
|
|