| Identification | More | [Name]
DL-ETHIONINE | [CAS]
67-21-0 | [Synonyms]
2-AMINO-4-ETHYLMERCAPTOBUTYRIC ACID
2-AMINO-4-(ETHYLTHIO) BUTYRIC ACID
DL-2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID
DL-ETHIONINE
S-ETHYL-DL-HOMOCYSTEINE
(.+/-.)-Ethionine
(+-)-ethionine
)-Ethionine
Aethionin
Butyric acid, 2-amino-4-(ethylthio)-, DL-
Butyric acid, DL-2-amino-4-(ethylthio)-
CN 8676
cn8676
dl-2-amino-4-(ethylthio)-butyricaci
dl-ethionin
DL-Homocysteine, S-ethyl-
ETH
Ethionin
Ethionine
Ethionine, DL- | [EINECS(EC#)]
200-647-0 | [Molecular Formula]
C6H13NO2S | [MDL Number]
MFCD00063102 | [Molecular Weight]
163.24 | [MOL File]
67-21-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
265-268 °C | [alpha ]
[α]D20 0±0.5° (c=5, dil. HCl) | [Boiling point ]
310℃ | [density ]
1.164 | [refractive index ]
1.5500 (estimate) | [Fp ]
142℃ | [storage temp. ]
−20°C
| [form ]
Crystalline Powder or Flakes | [pka]
2.23±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble in water. | [Merck ]
14,3738 | [BRN ]
1722529 | [CAS DataBase Reference]
67-21-0(CAS DataBase Reference) | [EPA Substance Registry System]
S-Ethylhomocysteine (67-21-0) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
ES6825200
| [TSCA ]
Yes | [HS Code ]
29309090 | [Safety Profile]
Mddly toxic by
ingestion and intraperitoneal routes.
Suspected carcinogen with experimental
carcinogenic and tumorigenic data. An
experimental teratogen. Experimental reproductive effects. Mutation data
reported. When heated to decomposition it
emits toxic fumes of SOx and NOx. | [Toxicity]
The Sethyl
analog of methionine. It is a carcinogen and hepatotoxic
agent once proposed as an antineoplastic agent. It inhibits the
incorporation of methionine and glycine into proteins and substitutes
for methionine in transmethylation reactions, the ethyl
group appearing in the products in place of the methyl groups
of methionine (e.g., ethylcholine is formed instead of choline).
Ethionine is currently used only as an experimental compound
in studies of hepatotoxicity and methionine metabolism and
nutrition. |
| Hazard Information | Back Directory | [General Description]
White crystalline flakes. | [Reactivity Profile]
A synthetic thio-substituted amino acid. | [Air & Water Reactions]
Slightly soluble in water. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of NOx and SOx. | [Fire Hazard]
Flash point data for this chemical are not available; however, DL-ETHIONINE(67-21-0) is probably combustible. | [Chemical Properties]
Off-White Solid | [Uses]
antineoplastic; inhibitor DNA methylation | [Uses]
DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. It is also used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione. | [Definition]
ChEBI: A non-proteinogenic alpha-amino acid that is methionine in which the S-methyl group is replaced by an S-ethyl group. | [Biochem/physiol Actions]
DL-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. DL-Ethionine is used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione. |
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