| Identification | More | [Name]
Methylaminoformyl chloride | [CAS]
6452-47-7 | [Synonyms]
METHYLAMINOFORMYL CHLORIDE
n-methylaminoformyl chloride
METHYLCARBAMOYLCHLORIDE
Methylcarbamic chloride
N-Methylchloroformamide
Methylcarbamic acid chloride
N-(Chloroformyl)methylamine
N-Methylcarbamoyl chloride | [EINECS(EC#)]
229-253-7 | [Molecular Formula]
C2H4ClNO | [MDL Number]
MFCD08703300 | [Molecular Weight]
93.51 | [MOL File]
6452-47-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
45°C | [Boiling point ]
93°C (dec.) | [density ]
1.185±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Acetonitrile, Chloroform (Slightly), DMSO | [form ]
Solid | [pka]
10.67±0.46(Predicted) | [color ]
White to Off-White | [Stability:]
Air Sensitive, Hygroscopic, Moisture Sensitive, Volatile | [CAS DataBase Reference]
6452-47-7(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Description]
Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.
| [Uses]
Methylaminoformyl chloride can be widely used as an intermediate of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine and carbaryl.
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.
| [Preparation]
Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3].
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