| Identification | Back Directory | [Name]
3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate | [CAS]
641569-96-2 | [Synonyms]
NILOTINIB IMPURITY 22
Nilotinib Impurity 35
ethyl 3-guanidino-4-methylbenzoate
Ethyl 3-guanidino-4-methylbenzoate nitrate
Ethyl 3-Carbamimidoylamino-p-toluate Nitrate
Ethyl 3-Carbamimidoylamino-4-methylbenzoate Nitrate
3-Carbamimidoylamino-p-toluic Acid Ethyl Ester Nitrate
Ethyl 3-Carbamimidoylamino-4-methylbenzoate Nitrate >
3-Carbamimidoylamino-4-methylbenzoic Acid Ethyl Ester Nitrate
3-(hydrazinylmethylideneamino)-4-methylbenzoic acid ethyl ester
3-[(AMinoiMinoMethyl)aMino]-4-Methylbenzoic acid ethyl ester Mon
3-[(Aminoimethyl)amino]-4-methylbenzoic acid ethyl estermononitrate
((aminoiminomethyl)amino)-4-methylbenzoic acid ethyl ester mononitrate
3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate | [Molecular Formula]
C11H16N4O5 | [MDL Number]
MFCD11100711 | [MOL File]
641569-96-2.mol | [Molecular Weight]
284.27 |
| Chemical Properties | Back Directory | [Melting point ]
197.0 to 201.0 °C | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
powder to crystal | [color ]
White to Almost white |
| Hazard Information | Back Directory | [Chemical Properties]
3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate Appearance white to almost white powder to crystals, melting point 199 °C, storage 2-8 °C. | [Uses]
3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate is an organic synthetic material or pharmaceutical intermediate compound that can be used in the preparation of N-phenyl-2-pyrimidinamine derivatives and in the synthesis of nilotinib and its salts. Nilotinib is a tyrosine kinase inhibitor used for the treatment of drug-resistant chronic myelogenous leukemia (CML), and in particular, for the treatment of chronic phase and accelerated phase Philadelphia chromosome positive chronic myeloid leukemia (CML) in adult patients whose disease has progressed on or who cannot tolerate other therapies that included imatinib. Nilotinib is administrated as a hydrochloride salt in the form of capsules that are marketed in the USA and the EU under the name Tasigna?. |
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