| Identification | More | [Name]
Carbocistein | [CAS]
638-23-3 | [Synonyms]
3-[(CARBOXYMETHYL)THIO]ALANINE
3-CARBOXYMETHYLTHIO-L-ALANINE
CARBOCYSTEINE
CARBOXYMETHYLCYSTEINE
CARBOXYMETHYL-L-CYSTEINE
H-CYS(CARBOXYMETHYL)-OH
H-L-CYS(ACOH)-OH
L-CYSTEINE, S-(CARBOXYMETHYL)-
(R)-2-AMINO-3-(CARBOXYMETHYLTHIO)PROPIONIC ACID
(l)-2-amino-3-(carboxymethylthio)propionicacid
(r)-s-(carboxymethyl)cysteine
carbocisteine
l.j.206
l-3-((carboxymethyl)thio)alanine
l-carboxymethylcysteine
rhinathiol
rinatiol
s-(carboxymethyl)-(r)-cysteine
s-(carboxymethyl)-l-cystein
s-carboxylmethyl-l-cysteine | [EINECS(EC#)]
211-327-5 | [Molecular Formula]
C5H9NO4S | [MDL Number]
MFCD00002614 | [Molecular Weight]
179.19 | [MOL File]
638-23-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly off-white amorphous powder | [Melting point ]
208-213 °C (dec.)
| [alpha ]
-31 º (c=1, 10% NaH2CO3) | [Boiling point ]
417.3±45.0 °C(Predicted) | [density ]
1.315 (estimate) | [refractive index ]
1.5216 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Aqueous Acid, Aqueous Base (Sparingly, Sonicated) | [form ]
Amorphous Powder | [pka]
2.06±0.10(Predicted) | [color ]
White to slightly off-white | [Water Solubility ]
SOLUBLE IN COLD WATER | [Merck ]
14,1802 | [BRN ]
1725012 | [LogP]
0.204 (est) | [Uses]
carbocysteine is an amino acid. It can be used to help control sebum production. | [CAS DataBase Reference]
638-23-3(CAS DataBase Reference) | [EPA Substance Registry System]
638-23-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
2
| [RTECS ]
AY4342000
| [TSCA ]
Yes | [HS Code ]
29309090 | [Safety Profile]
contact. A riot control agent. When heated | [Toxicity]
LD50 oral in rat: > 15gm/kg |
| Hazard Information | Back Directory | [Chemical Properties]
white to slightly off-white amorphous powder | [Originator]
Rhinathiol,Kramer,Switz. | [Definition]
ChEBI: S-carboxymethyl-L-cysteine is an L-cysteine thioether that is L-cysteine in which the hydrogen of the thiol group has been replaced by a carboxymethyl group. It has a role as a mucolytic. It is a L-cysteine thioether and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a S-carboxylatomethyl-L-cysteine(1-). | [Manufacturing Process]
There were placed 120g of L-cysteine (0.5 mol) in a 2 liter three-necked flask
equipped with a stirrer thermometer and methanol/dry ice cooling and 1.5
liters of liquid ammonia were allowed to enter at -40°C. Then there were
added under continuous cooling 50 g (2.17 mols) of sodium metal in portions
of 1 to 2 g during the course of one hour. The end of the reaction was
recognized by the continuation of the blue color. After the end of the reaction
the excess sodium was destroyed by the addition of ammonium chloride and
the ammonia vaporized at normal pressure. The residue was taken up in 500
ml of water and concentrated in a vacuum to 200 ml in order to remove
residual ammonia, and again treated with 300 ml of water. The entire
operations were carried out under a nitrogen atmosphere.
The aqueous solution of the disodium salt of L-cysteine obtained is then
reacted at 20°C to 30°C under a nitrogen atmosphere in the course of 30
minutes with stirring with a solution of 104 g of chloroacetic acid (1.1 mols)
and 4 g of sodium pyrosulfite in 200 ml of water. It is also allowed to post
react for 15 minutes at 20°C, the solution clarified over activated carbon and
the filtrate treated with 90 ml of concentrated hydrochloric acid to a pH of
2.5.
Thereby the S-carboxymethyl-L-cysteine precipitates out in crystalline form.
The product is filtered off with suction, well stirred in 500 ml of water, again
filtered with suction and dried in a vacuum at 70°C. The yield is 92% based
on L-cysteine. | [Brand name]
Loviscol
(Wyeth-Ayerst); Mucofan (Wyeth-Ayerst). | [Therapeutic Function]
Mucolytic, Expectorant, Nasal antiinfective | [Biochem/physiol Actions]
S-Carboxymethyl-L-cysteine is studied as a small molecule mucoactive drug in vivo. These studies include analyzing the oxidative metabolism of S-carboxymethyl-L-cysteine by enzymes such as phenylalanine monooxygenase(s). |
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