| Identification | More | [Name]
2,4,6-Trichloroaniline | [CAS]
634-93-5 | [Synonyms]
1-Amino-2，4，6-trichlorobenzene
2,4,6-TRICHLOROANILINE
2,4,6-trichlorobenzenamine
2,4,6-tca
2,4,6-trichloraniline
2,4,6-trichloro-anilin
2,4,6-trichloro-benzenamin
2,4,6-Trichlorophenylamine
Aniline, 2,4,6-trichloro-
aniline,2,4,6-trichloro-
benzenamine,2,4,6-trichloro-
s-Trichloroaniline
sym-Trichloroaniline
2,4,6-TRICHLOROANILINE PESTANAL, 250 MG
2,4,6-Trichloroaniline, 98.50%
2,4,6-Trichloranilin
2,4,6-Trichloroaniline, 98+%
2,4,6-Trichloroanyline
2,4,6-Trichlorobenzeneamine | [EINECS(EC#)]
211-219-8 | [Molecular Formula]
C6H4Cl3N | [MDL Number]
MFCD00007663 | [Molecular Weight]
196.46 | [MOL File]
634-93-5.mol |
| Chemical Properties | Back Directory | [Appearance]
fine purple fibres | [Melting point ]
73-75 °C (lit.) | [Boiling point ]
262 °C (lit.) | [density ]
1.6807 (rough estimate) | [vapor pressure ]
0-0.631Pa at 25℃ | [refractive index ]
1.6300 (estimate) | [Fp ]
262°C | [storage temp. ]
Storage temperature: no restrictions. | [solubility ]
0.039g/l slightly soluble | [form ]
neat | [pka]
0.07±0.10(Predicted) | [color ]
Needles or liquid from pet ether | [Stability:]
Stable, but may be light or air sensitive. Incompatible with acids, acid chlorides, acid anhydrides, chloroformates, strong oxidizing agents. | [Water Solubility ]
<0.1 g/100 mL at 21.5 ºC | [BRN ]
879568 | [InChIKey]
NATVSFWWYVJTAZ-UHFFFAOYSA-N | [LogP]
3.648-3.69 at 25℃ | [CAS DataBase Reference]
634-93-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 2,4,6-trichloro-(634-93-5) | [EPA Substance Registry System]
634-93-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
BZ0250000
| [Hazard Note ]
Toxic | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29214200 | [Hazardous Substances Data]
634-93-5(Hazardous Substances Data) | [Toxicity]
LD50 orl-rat: 2400 mg/kg GISAAA 55(6),86,90 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Aniline | [Preparation Products]
1,3,5-Trichlorobenzene-->4-Amino-3,5-dichloroacetophenone-->2,2',4,4',6,6'-HEXACHLOROBIPHENYL-->2,4,6-Trichloroiodobenzene-->1-BROMO-2,4,6-TRICHLOROBENZENE-->2,2',3,4,4',5,6,6'-OCTACHLOROBIPHENYL-->1,2,3,5-Tetrachlorobenzene-->2-azido-1,3,5-trichlorobenzene |
| Hazard Information | Back Directory | [General Description]
Long needles or fine, light purple fibers. | [Reactivity Profile]
2,4,6-TRICHLOROANILINE(634-93-5) is incompatible with acids, acid chlorides, acid anhydrides, chloroformates, and strong oxidizing agents. . | [Air & Water Reactions]
This compound may be sensitive to exposure to light and air. Insoluble in water. | [Fire Hazard]
Flash point data for this chemical are not available. 2,4,6-TRICHLOROANILINE is probably combustible. | [Description]
Trichloroaniline is particularly important as a chemical intermediate in manufacturing many benzene derivatives and other organic compounds. For instance, 2,4,6-trichloroaniline is an essential precursor of 1,3,5-trichlorobenzene. The latter has been extensively studied and developed for insecticides and fungicides. It, in turn, is a precursor of trichlorodinitrobenzene, which is especially important in combatting crop diseases and is an intermediate for dyestuffs. In military applications, 2,4,6-trichloroaniline is utilized for the preparation of insensitive energetic material that is employed in several Navy weapons systems. The synthesis of 2,4,6-trichloroaniline has almost invariably been accomplished by chlorinating aniline with chlorine or sulfuryl chloride.
| [Chemical Properties]
fine purple fibres | [Uses]
Tetrachloronitrobenzene was prepared from 2:4:6-trichloroaniline,which was converted by a Sandmeyer reaction into 1:2:3:5- tetrachlorobenzene. | [Preparation]
2,4,6-Trichloroaniline can be prepared by reaction of dry aniline with chlorine gas while in a anhydrous solution of carbon tetrachloride. 2,4,6-Trichloroaniline precipitates from solution as a white solid. If water is introduced to the solution the white material will polymerize to form aniline black.
Process for the preparation of 2,4,6-trichloroaniline | [Safety Profile]
Moderately toxic by ingestion.Irritant. Questionable carcinogen with experimentalcarcinogenic data. Mutation data reported. When heatedto decomposition it emits very toxic fumes of Clí andNOx. | [Purification Methods]
Crystallise the aniline from ligroin. The benzoyl derivative has m 174o (from EtOH). [Beilstein 12 H 627, 12 IV 1281.] |
| Questions And Answer | Back Directory | [Genotoxicity]
Limited information is available regarding the potential genotoxicity of 2,4,6-trichloroaniline. 2,4,6-Trichloroaniline did not induce mutations in Salmonella typhimurium strains TA98, TA100, or TA1537 in the presence or absence of metabolic activation in plate-incorporation assays; microsomal-suspension assays using the same strains and metabolic-activation preparations were also negative. However, using the preincubation method, 2,4,6-trichloroaniline tested positive for mutagenicity in Salmonella and Escherichia coli (strains not specified). 2,4,6-Trichloroaniline tested negative in the Salmonella umu (SOS response) assay and failed to induce DNA repair in rat hepatocytes. In vivo, 2,4,6-trichloroaniline was mutagenic in the wing spot test in Drosophila. Rats treated orally with 2,4,6-trichloroaniline at 40 mg/kg-day (but not 0.4 or 4 mg/kg-day) for 6 months showed a small but statistically significant increase (p < 0.05) in the number of bone marrow cells containing chromosomal aberrations when compared with controls (1.6% vs. 0.4%, respectively); however, this study did not provide any study design details.
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| Spectrum Detail | Back Directory | [Spectrum Detail]
2,4,6-Trichloroaniline(634-93-5)MS
2,4,6-Trichloroaniline(634-93-5)1HNMR
2,4,6-Trichloroaniline(634-93-5)13CNMR
2,4,6-Trichloroaniline(634-93-5)IR1
2,4,6-Trichloroaniline(634-93-5)IR2
2,4,6-Trichloroaniline(634-93-5)IR3
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