| Identification | More | [Name]
1,2,3,5-Tetrachlorobenzene | [CAS]
634-90-2 | [Synonyms]
1,2,3,5-TETRACHLOROBENZENE
1,2,3,5-tcb
1,2,3,5-tetrachloro-benzen
1,2,4,6-tetrachlorobenzene
benzene,1,2,3,5-tetrachloro-
chlorinatedbenzenes,tri-,tetra-andpenta-
tetrachloro1,2,3,5-benzene
1,2,3,5-TETRACHLOROBENZENE OEKANAL, 250
1,2,3,5-TETRACHLOROBENZENE, 1X1ML MEOH 2 000UG/ML
1,2,3,5-tetrachlorobenzene solution
1,3,4,5-Tetrachlorbenzol
,2,3,5-TETRACHLOROBENZENE | [EINECS(EC#)]
211-217-7 | [Molecular Formula]
C6H2Cl4 | [MDL Number]
MFCD00000543 | [Molecular Weight]
215.89 | [MOL File]
634-90-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
54.5°C | [Boiling point ]
246°C | [density ]
1.5578 (estimate) | [vapor pressure ]
0.07 at 25 °C (extrapolated, Mackay et al., 1982) | [refractive index ]
1.5348 (estimate) | [Fp ]
113 °C | [storage temp. ]
APPROX 4°C
| [solubility ]
Soluble in alcohol, benzene, ether, and ligroin (Weast, 1986) | [form ]
neat | [color ]
White to Almost white | [Water Solubility ]
4.016mg/L(25 ºC) | [BRN ]
1618864 | [Henry's Law Constant]
58.0 at 25 °C (gas stripping-GC, Shiu and Mackay, 1997) | [CAS DataBase Reference]
634-90-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzene, 1,2,3,5-tetrachloro-(634-90-2) | [EPA Substance Registry System]
634-90-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T,F | [Risk Statements ]
R22:Harmful if swallowed.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
S7:Keep container tightly closed . | [RIDADR ]
UN 1230 3/PG 2 | [WGK Germany ]
3 | [RTECS ]
DB9445000 | [HS Code ]
2903.99.8001 | [Hazardous Substances Data]
634-90-2(Hazardous Substances Data) | [Toxicity]
Acute oral LD50 for rats 1,727 mg/kg (quoted, RTECS, 1985). |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Cyclohexene, 1,2,3,4,5,6-hexachloro-, (3alpha,4beta,5beta,6alpha)--->Cyclohexene, 1,2,3,4,5,6-hexachloro--->1,2,3,4-Tetrachlorobenzene-->1-BROMO-2,4,6-TRICHLOROBENZENE-->2,4,6-Trichlorophenylhydrazine-->2,2',4,4',6,6'-HEXACHLOROBIPHENYL-->Methanol-->Dimethyl malonate-->2,4,6-Trichloroaniline-->1,3,5-Trichlorobenzene | [Preparation Products]
2,4,5-Trichlorophenol-->1,2,4,5-Tetrachlorobenzene |
| Hazard Information | Back Directory | [General Description]
White crystals or off-white solid. | [Reactivity Profile]
Simple aromatic halogenated organic compounds, such as 1,2,3,5-TETRACHLOROBENZENE(634-90-2), are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. This chemical may react with oxidizers. . | [Air & Water Reactions]
Insoluble in water. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: This compound may cause irritation on contact. | [Fire Hazard]
This chemical is probably combustible. | [Uses]
1,2,3,5-Tetrachlorobenzene is used in the synthesis of several organic compounds including that of polyarylated benzenes by multiple Suzuki-Miyaura reactions. It was used as part of study which investigated the antimicrobial activity of tetra substituted benzene derivatives which suggested antimicrobial activity tended to decrease with increasing size of halogen substituents. | [Definition]
ChEBI: A tetrachlorobenzene carrying chloro groups at positions 1, 2, 3 and 5. | [Environmental Fate]
Biological. A mixed culture of soil bacteria or a Pseudomonas sp. transformed 1,2,3,5-tetrachlorobenzene
to 2,3,4,6-tetrachlorophenol (Ballschiter and Scholz, 1980). The half-life of 1,2,3,5-
tetrachlorobenzene in an anaerobic enrichment culture was 1.8 d (Beurskens et al., 1993).
In an enrichment culture derived from a contaminated site in Bayou d’Inde, LA, 1,2,3,5-
tetrachlorobenzene underwent reductive dechlorination to 1,2,4- and 1,3,5-trichlorobenzene at
relative molar yields of 7 and 93%, respectively. The maximum dechlorination rate, based on the
recommended Michaelis-Menten model, was 94 nM/d (Pavlostathis and Prytula, 2000).
Photolytic. Irradiation (λ ≥285 nm) of 1,2,3,5-tetrachlorobenzene (1.1–1.2 mM/L) in an
acetonitrile-water mixture containing acetone (0.553 mM/L) as a sensitizer gave the following
products (% yield): 1,2,3-trichlorobenzene (5.3), 1,2,4-trichlorobenzene (4.9), 1,3,5-trichlorobenzene
(49.3), 1,3-dichlorobenzene (1.8), 2,3,4,4′,5,5′,6-heptachlorobiphenyl (1.41), 2,2′,3,4,4′,6,6′-
heptachlorobiphenyl (1.10), 2,2′,3,3′,4,5′,6-heptachlorobiphenyl (4.50), four hexachlorobiphenyls
(4.69), one pentachlorobiphenyl (0.64), trichloroacetophenone, 1-(trichlorophenyl)-2-propanone,
and (trichlorophenyl)acetonitrile (Choudhry and Hutzinger, 1984). Without acetone, the identified
photolysis products (% yield) included 1,2,3-trichlorobenzene (trace), 1,2,4-trichlorobenzene
(24.3), 1,3,5-trichlorobenzene (11.7), 1,3-dichlorobenzene (0.5), 1,4-dichlorobenzene (3.3),
pentachlorobenzene (1.43), 1,2,3,4-tetrachlorobenzene (5.99), two heptachlorobiphenyls (1.40),
two hexachlorobiphenyls (<0.01), and one pentachlorobiphenyl (0.75) (Choudhry and Hutzinger,
1984). | [Purification Methods]
Crystallise it from EtOH. [Beilstein 5 II 157, 5 III 551, 5 IV 668.] |
| Spectrum Detail | Back Directory | [Spectrum Detail]
1,2,3,5-Tetrachlorobenzene(634-90-2)MS
1,2,3,5-Tetrachlorobenzene(634-90-2)1HNMR
1,2,3,5-Tetrachlorobenzene(634-90-2)13CNMR
1,2,3,5-Tetrachlorobenzene(634-90-2)IR1
1,2,3,5-Tetrachlorobenzene(634-90-2)IR2
1,2,3,5-Tetrachlorobenzene(634-90-2)IR3
1,2,3,5-Tetrachlorobenzene(634-90-2)Raman
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