| Identification | More | [Name]
BETA-HYDROXYISOVALERIC ACID | [CAS]
625-08-1 | [Synonyms]
3-B-HYDROXYBUTYRIC ACID
3-HYDROXY-3-METHYLBUTANOIC ACID
3-HYDROXY-3-METHYL BUTYRIC ACID
BETA-HYDROXY-3-METHYL BUTYRIC ACID
BETA-HYDROXY BETA-METHYLBUTYRATE
BETA-HYDROXYISOVALERIC ACID
HMB
HYDROXYISOVALERIC ACID, BETA-
RARECHEM AL BO 2324
?Hydroxyisovaleric acid
β-Hydroxy-β-MethylButyric acid
(S)-2-Hydroxyisovaleric Acid
3-Hydroxyisovaleric acid
HYDROXY-METHYLBUTYRATE
SS-HYDROXYISOVALERIC ACID
3-HYDROXY-3-METHYL BUTYRIC ACID 98%
3-Methyl-3-hydroxybutanoic acid
β-Hydroxy-β-methylbutanoic acid | [EINECS(EC#)]
626-699-8 | [Molecular Formula]
C5H10O3 | [MDL Number]
MFCD00059081 | [Molecular Weight]
118.13 | [MOL File]
625-08-1.mol |
| Chemical Properties | Back Directory | [Appearance]
colorless to light yellow liquid | [Melting point ]
-80 °C (lit.) | [Boiling point ]
88 °C/1 mmHg (lit.) | [density ]
0.938 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.4415(lit.)
| [Fp ]
113 °C | [storage temp. ]
Refrigerator | [solubility ]
DMF:10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);84.65(Max Conc. mM) | [form ]
Liquid | [pka]
4.38±0.10(Predicted) | [color ]
Pale yellow | [Specific Gravity]
1.10 | [Water Solubility ]
Soluble in water and ethanol. | [BRN ]
1743952 | [InChIKey]
AXFYFNCPONWUHW-UHFFFAOYSA-N | [CAS DataBase Reference]
625-08-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 3334 | [WGK Germany ]
3
| [F ]
10-13-21 | [HS Code ]
29181990 |
| Hazard Information | Back Directory | [Description]
β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β- methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. It plays a part in protein synthesis and was discovered by Dr. Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pigs, and small quantities can also be found in grapefruit, alfalfa, and catfish. As a supplement it is usually sold as a calcium salt.
Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research. The same study lists as HMB' s proposed mechanisms of action the following:
Increased sarcolemmal integrity via conversion to HMG-CoA
Enhanced protein synthesis via the mTOR pathway
Depression of protein degradation through inhibition of the ubiquitin pathway
Three grams of Calcium beta-hydroxy-beta-methylbutyrate per day may help muscles combat protein breakdown, assist in muscle repair and support increased endurance. Studies suggest its benefits may be greater for the untrained. Also, well-controlled scientific studies have found increases in muscle mass and decreases in body fat in 70 year old men. It has helped patients with chronic obstructive pulmonary disease in hospital intensive care units, muscle wasting associated with HIV or AIDS and with cancer, and trauma victims with severe injuries.
The human body produces about 0.2 - 0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses. | [Chemical Properties]
colorless to light yellow liquid | [Uses]
β-Hydroxyisovaleric Acid is a metabolite of the essential amino acid Leucine and is synthesized in the human body. Studies suggest that β-Hydroxyisovaleric Acid may have an effect on increasing muscle weight and strength. The presence of elevated β-Hydroxyisovaleric Acid is a sensitive marker of biotin deficiency and may indicate the presence of a genetic disorder such as biotinidase deficiency or holocarboxylase synthetase deficiency. | [Definition]
ChEBI: A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency. | [storage]
Store at -20°C |
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