| Identification | More | [Name]
Potassium citrate monohydrate | [CAS]
6100-05-6 | [Synonyms]
2-HYDROXY-1,2,3-PROPANE-TRICARBOXYLIC ACID TRIPOTASSIUM SALT, MONOHYDRATE
AQUALINE(R) TRI-POTASSIUM CITRATE STANDARD
AQUALINE STANDARD KF OVEN
CITRIC ACID POTASSIUM SALT MONOHYDRATE
CITRIC ACID TRIPOTASSIUM SALT
CITRIC ACID TRIPOTASSIUM SALT HYDRATE
CITRIC ACID TRIPOTASSIUM SALT MONOHYDRATE
KALII CITRAS
POTASSIUM CITRATE
POTASSIUM CITRATE-1-HYDRATE
POTASSIUM CITRATE, MONOHYDRATE
POTASSIUM CITRATE TRIBASIC
POTASSIUM CITRATE TRIBASIC HYDRATE
POTASSIUM CITRATE, TRIBASIC MONOHYDRATE
TRI-POTASSIUM CITRATE
TRI-POTASSIUM CITRATE H2O
TRIPOTASSIUM CITRATE MONOHYDRATE
citric acid tripotassium cell culture*tested
HYDRANAL-WATER STANDARD KF-OVEN
CITRIC ACID TRIPOTASSIUM CRYSTALLINE | [EINECS(EC#)]
231-905-0 | [Molecular Formula]
C6H7K3O8 | [MDL Number]
MFCD00150442 | [Molecular Weight]
324.41 | [MOL File]
6100-05-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White/clear crystalline powder | [Melting point ]
275 °C (dec.)(lit.)
| [density ]
1.98 | [storage temp. ]
Store at RT. | [solubility ]
H2O: 1 M at 20 °C, clear, colorless
| [form ]
Granular | [color ]
White crystalline | [Specific Gravity]
1.98 | [Odor]
Odorless | [PH]
7.5-9.0 (25℃, 50mg/mL in H2O) | [PH Range]
8 - 9.5 | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
Soluble in water and glycerol. Practically insoluble in alcoholSoluble in water and glycerol. Insoluble in alcohol | [Merck ]
14,7623 | [BRN ]
3924344 | [InChIKey]
PJAHUDTUZRZBKM-UHFFFAOYSA-K | [Uses]
Potassium Citrate, Monohydrate is a sequestrant and buffer that
exists as crystals or powder. it is slightly hygroscopic and possesses
the advantageous properties of citric acid without having its acid
reaction. a 1% solution has a ph of 7.5–9.0. it reacts with metal ions
such as calcium, magnesium, and iron to form a complex. it is soluble
in water with a solubility of 1.8 g in 1 ml of 20°c water and 2 g in
1 ml of 80°c water. it is found in artificially sweetened jelly and in
certain milk and meat products. uses include processed cheese, pud-
dings, and dietetic foods in which sodium is undesirable. it is also
termed tripotassium citrate. | [CAS DataBase Reference]
6100-05-6(CAS DataBase Reference) | [EPA Substance Registry System]
6100-05-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,T,C,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R35:Causes severe burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
1
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
29181500 |
| Hazard Information | Back Directory | [Chemical Properties]
Transparent prismatic crystals or a white, granular powder.
Potassium citrate is hygroscopic and odorless, and has a cooling,
saline taste. | [Chemical Properties]
White/clear crystalline powder | [Definition]
ChEBI: A hydrate that is the monohydrate form of potassium citrate. | [Production Methods]
Potassium citrate is prepared by adding either potassium bicarbonate or potassium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is then filtered and evaporated to dryness to obtain potassium citrate. | [General Description]
Potassium citrate tribasic monohydrate (KCTM) is a potassium salt that has been reported to be efficient in forming aqueous two-phase system (ATPS) with UCON 50-HB-5100, a random copolymer. This product is a high quality pharmacopoeia product that meets the testing specifications of USP (United States Pharmacopoeia). It can be employed in research and pilot studies. | [Pharmaceutical Applications]
Potassium citrate is used in beverages, foods, and oral pharmaceutical
formulations as a buffering and alkalizing agent. It is also used
as a sequestering agent and as a therapeutic agent to alkalinize the
urine and to relieve the painful irritation caused by cystitis. | [Biochem/physiol Actions]
Potassium citrate can be used to prepare citrate water that supports the survival of streptozotocin (STZ)-diabetic mice. It might reduce the successive stone formation in calcium nephrolithiasis. Potassium citrate serves as an activator for producing activated carbons. | [Side effects]
The most common side effects of potassium citrate are gastrointestinal. Potassium citrate can be irritating to the stomach. Potassium citrate may cause an upset stomach, nausea or vomiting, and diarrhea or loose stools. | [Safety]
Potassium citrate is used in oral pharmaceutical formulations and is
generally regarded as a nontoxic and nonirritant material by this
route of administration.
Most potassium citrate safety data relate to its use as a
therapeutic agent, for which up to 10 g may be administered daily,
in divided doses, as a treatment for cystitis. Although there are
adverse effects associated with excessive ingestion of potassium
salts, the quantities of potassium citrate used as a pharmaceutical
excipient are insignificant in comparison to those used therapeutically.
(IV, dog): 0.17 g/kg | [storage]
Potassium citrate is a stable, though hygroscopic material, and
should be stored in an airtight container in a cool, dry place. It is
deliquescent in moist air. | [Purification Methods]
It solubility in H2O is 154% and it loses H2O at 180o. [Beilstein 3 III 1091.] | [Incompatibilities]
Aqueous potassium citrate solutions are slightly alkaline and will
react with acidic substances. Potassium citrate may also precipitate
alkaloidal salts from their aqueous or alcoholic solutions. Calcium
and strontium salts will cause precipitation of the corresponding
citrates. Potassium citrate is incompatible with strong oxidizing
agents. | [Regulatory Status]
GRAS listed. Accepted as a food additive in Europe. Included in the
FDA Inactive Ingredients Database (oral solutions and suspensions;
topical emulsions and aerosol foams). Included in nonparenteral
medicines (cutaneous foams and emulsions; oral liquids, granules,
mixtures and soluble tablets; topical liquids, emulsions and
mousses) licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients. |
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