| Identification | More | [Name]
Dansyl chloride | [CAS]
605-65-2 | [Synonyms]
1-DIMETHYLAMINO-NAPHTHALENE-5-SULFONYL CHLORIDE
1-DIMETHYLAMINONOPHTHALENE-5-SULPHONYL CHLORIDE
5-DIMETHYLAMINO-1-NAPHTHALENESULFONYL CHLORIDE
5-DIMETHYLAMINO-1-NAPTHALENESULFONYL CHLORIDE
5-DIMETHYLAMINONAPHTHALENE-1-SULFONYL CHLORIDE
5-DIMETHYLAMINONAPHTHALENE-1-SULFONYL CHLORIDE ACETONE
5-DIMETHYLAMINONAPHTHALENE-1-SULPHONYL CHLORIDE
5-(DIMETHYLAMINO)-NAPTHALENE-1-SULFONYL CHLORIDE
DANSYL CHLORIDE
DENSYL CHLORIDE
DNS
DNSCL
N,N-DIMETHYL-1-NAPHTHYLAMINE-5-SULFONYL CHLORIDE
1-(dimethylamino)-5-naphthalenesulfonylchloride
1-chlorosulfonyl-5-dimethylaminonaphthalene
5-(dimethylamino)-1-naphthalenesulfonylchlorid
5-dimethylaminonaphthyl-5-sulfonylchloride
dansyl
dimethylaminonaphthalenesulfonylchloride
5-Dimethylamino-1-naphthalenesulphonyl chloride~DNSCl | [EINECS(EC#)]
210-092-6 | [Molecular Formula]
C12H12ClNO2S | [MDL Number]
MFCD00003985 | [Molecular Weight]
269.75 | [MOL File]
605-65-2.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to orange-yellow crystalline powder | [Melting point ]
72-74 °C(lit.)
| [Boiling point ]
371.3±22.0 °C(Predicted) | [density ]
1.1702 (rough estimate) | [refractive index ]
1.5630 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
acetone: 50 mg/mL
| [form ]
powder and chunks
| [pka]
2.38±0.40(Predicted) | [color ]
yellow to orange
| [Water Solubility ]
Soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water. | [Sensitive ]
Moisture Sensitive | [Detection Methods]
HPLC,NMR | [Merck ]
14,2814 | [BRN ]
2217205 | [InChIKey]
XPDXVDYUQZHFPV-UHFFFAOYSA-N | [CAS DataBase Reference]
605-65-2(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive;Store under nitrogen | [EPA Substance Registry System]
605-65-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S3:Keep in a cool place . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
QK3688000
| [F ]
10-21 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29214980 | [Safety Profile]
Poison by intravenous
route, When heated to decomposition it
emits very toxic fumes of Cland NOx |
| Questions And Answer | Back Directory | [Uses]
Dansyl chloride or 5-Dimethylaminonaphthalene-1-sulfonyl chloride (CAS 605-65-2) is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.
Dansyl chloride is non-fluorescent until it reacts with amines. The resulting Dansyl amides have environmentally sensitive fluorescence quantum yields and emission maxima along with large Stokes shifts. This environment-sensitive fluorescence property has made Dansyl chloride an important tool for biophysical studies.
|
| Hazard Information | Back Directory | [Chemical Properties]
yellow to orange-yellow crystalline powder | [Definition]
ChEBI: Dansyl chloride is an aminonaphthalene and a sulfonic acid derivative. | [General Description]
Dansyl chloride is a fluorogenic reagent which is typically employed for the derivatization of amino acids. | [Biochem/physiol Actions]
Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins. Dansyl chloride is used for derivatization of free amino acids and amines in neural samples and biological fluids. It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization. |
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