| Identification | More | [Name]
PROXYPHYLLINE | [CAS]
603-00-9 | [Synonyms]
[1,3-DIMETHYL-7-(2-HYDROXYPROPYL)-2,6-DIOXOPURINE]
7-(BETA-HYDROXYPROPYL)THEOPHYLLINE
PROXYPHYLINE
PROXYPHYLLIN
PROXYPHYLLINE
1,3-Dimethyl-7-(2-hydroxypropyl)xanthine
1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-
1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-
2-Hydroxypropyl-7-theophylline
3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-1h-purine-6-dione
3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione
3,7-dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1h-purine-6-dione
7-(2-Hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
7-(2-hydroxypropyl)-theophyllin
7-(2-Hydroxypropyl)theophylline
7-(beta-Hydroxypropyl)-1,3-dimethylxanthine
beta-Hydroxypropyltheophylline
beta-Oxypropyltheophyllin
Brontyl
Hydroxypropyltheophylline | [EINECS(EC#)]
210-028-7 | [Molecular Formula]
C10H14N4O3 | [MDL Number]
MFCD00022833 | [Molecular Weight]
238.24 | [MOL File]
603-00-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
134-136°C | [Boiling point ]
487.2±51.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Solution S is clear (2.2.1) and colourless (2.2.2, Method II). | [form ]
neat | [pka]
14.55±0.20(Predicted) | [color ]
White to Off-White | [Water Solubility ]
285.7g/L(temperature not stated) | [Merck ]
14,7905 | [CAS DataBase Reference]
603-00-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Proxyphylline(603-00-9) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
XH5907500
| [HS Code ]
2939.59.0000 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A metabolite of Theophylline in human plasma. | [Definition]
ChEBI: Proxyphylline is an oxopurine. | [Biological Activity]
ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors. | [in vitro]
previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1]. | [in vivo]
in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2]. | [Purification Methods]
Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.] | [References]
[1] u. schwabe, d. ukena and m. j. lohse. xanthine derivatives as antagonists at a1 and a2 adenosine receptors. naunyn-schmiedeberg's arch.pharmacol. 330,212-221 (1985).
[2] s. bang, y. s. kim and s. r. jeong. anti-allodynic effect of theoesberiven f in a vincristine-induced neuropathy model. exp. ther. med. 12(2), 799-803 (2016).
[3] selvig k. pharmacokinetics of proxyphylline in adults after intravenous and oral administration. eur j clin pharmacol. 1981 jan;19(2):149-55. |
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