| Identification | Back Directory | [Name]
SMI-16a | [CAS]
587852-28-6 | [Synonyms]
SMI-16a
SMI-16A;SMI 16A;SMI16A
PIM1/2 Kinase Inhibitor VI
SMI-16a(PIM1/2 Kinase Inhibitor VI)
2,4-Thiazolidinedione, 5-[(4-propoxyphenyl)methylene]- | [Molecular Formula]
C13H13NO3S | [MDL Number]
MFCD31382191 | [MOL File]
587852-28-6.mol | [Molecular Weight]
263.31 |
| Chemical Properties | Back Directory | [Melting point ]
186.3-188.4 °C | [density ]
1.303±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Ethanol:3.0(Max Conc. mg/mL);11.39(Max Conc. mM) | [form ]
A solid | [pka]
7.27±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
SMI-16a is a Pim-1 kinase inhibitor (IC50 = 63 nM).1 It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 μM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest at the G1 phase in DU145 cells. |
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| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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