| Identification | Back Directory | [Name]
SM 7368 | [CAS]
380623-76-7 | [Synonyms]
SM 7368
SM-7368
NFκB Activation Inhibitor III
3-Chloro-4-nitro-N-(5-nitrothiazol-2-yl)benzamide
3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide
NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem | [Molecular Formula]
C10H5ClN4O5S | [MDL Number]
MFCD00834007 | [MOL File]
380623-76-7.mol | [Molecular Weight]
328.69 |
| Chemical Properties | Back Directory | [density ]
1.761±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL (clear solution) | [form ]
powder | [pka]
5.18±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
NFkappaB Activation Inhibitor III is a TNF-α-stimulated NF kappa B activation inhibitor. | [Biological Activity]
nf-κb activation inhibitor iii is a nf-κb inhibitor.nf-κb (nuclear factor kappa-light-chain-enhancer of activated b cells) is a protein complex controling transcription of dna, cytokine production as well as cell survival. nf-κb is found in nearly all animal cell types and is involved in cellular responses to stimuli such as cytokines, stress, free radicals, heavy metals, and bacterial or viral antigens. | [in vitro]
previous study found that nf-κb activation inhibitor iii could inhibite tnf-a-induced mmp-9 upregulation in concentration-dependently and showed maximal activity at 10 μm. nf-κb activation inhibitor iii also inhibited tnf-a-induced mmp-9 mrna transcript accumulation and protein expression. it was also found that nf-κb activation inhibitor iii strongly inhibited tnf-a-induced nf-jb activity but not ap-1 activity. in addition, nf-κb activation inhibitor iii was able to strongly inhibit the tnf-a-induced invasion of ht1080 human fibrosarcoma cell line. these findings demonstrated that nf-κb activation inhibitor iii was a synthetic compound inhibiting tnf-a-induced mmp-9 expression, and therefore nf-κb activation inhibitor iii would be useful for the development of chemotherapy targeting tnf-a-mediated tumor invasion and metastasis [1]. nf-κb activation inhibitor iii was used to disrupt nf-κb signaling to evaluate the role of syndecans in mediating extracellular matrix integrity [2]. | [References]
[1] h. y. lee, k. s. park, m. k. kim, et al. a small compound that inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 upregulation. biochemical and biophysical research communications 336(2), 716-722 (2005).
[2] h. yang, h. liu, x. li, et al. tnf-α and tgf-β1 regulate syndecan-4 expression in nucleus pulposus cells: role of the mitogen-activated protein kinase and nf-κb pathways. connect.tissue res. 56(4), 281-287 (2015). |
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BOC Sciences
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DC Chemicals
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021-58447131 13564518121 |
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Energy Chemical
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InvivoChem
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https://www.invivochem.cn/ |
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