| Identification | More | [Name]
THROMBIN | [CAS]
581-64-6 | [Synonyms]
COAGULATION FACTOR FLA
COAGULATION FACTOR ILA
EC 3.4.21.5
EC: 3.4.21.5
FACTOR IIA
FIBRINOGENASE
Thionin hydrochloride
THROMBIN
THROMBIN, HUMAN
THROMBIN, HUMAN PLASMA
THROMBIN, TYPE 2, HUMAN PLASMA
3,7-diaminophenazathioniumchloride
3,7-diamino-phenothiazin-5-iuchloride
3,7-Diaminophenothiazoniumchloride
7-amino-3-imino-3h-phenothiazinmonohydrochloride
katalysin
lauthschesviolett
Phenothiazin-5-ium,3,7-diamino-,chloride
3,7-diaminophenothiazin-5-ium chloride
approx.90%dyecontent | [EINECS(EC#)]
232-648-7 | [Molecular Formula]
C12H10ClN3S | [MDL Number]
MFCD00082072 | [Molecular Weight]
263.746 | [MOL File]
581-64-6.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,B | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R42:May cause sensitization by inhalation. | [Safety Statements ]
S22:Do not breathe dust .
S24:Avoid contact with skin .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
2
| [RTECS ]
XO8950000
|
| Hazard Information | Back Directory | [Description]
Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin and potentiates the procoagulation process by activating factors V, VIII, XI, and XIII.1 Conversely, thrombin aids the anticoagulant process by activating protein C.2 Activated protein C inhibits activated factors V and VIII ultimately down-regulating further thrombin production. Thrombin is often used as a potent platelet activator in vitro. Platelet responses to thrombin are mediated through protease-activated receptors (PARs). 3 Thrombin-mediated signaling regulates a diverse range of metabolic processes including activation of phospholipases in platelets, endothelial cells, and cardiac myocytes.4 | [Chemical Properties]
dark green to black powder or crystals | [Uses]
Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess in vitro hemostatic properties of French lyophilized plasma. | [Uses]
Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess in vitro hemostatic properties of French lyophilized plasma.? | [Uses]
Thionine Chloride is used in the preparation of carbon paste electrode with covalently immobilized thionine for electrochemical sensing of hydrogen peroxide | [Definition]
ChEBI: An organic chloride salt composed of 3,7-diaminophenothiazin-5-ium and chloride ions in a 1:1 ratio. A strongly metachromatic dye, useful for the staining of acid mucopolysaccharides. It is also a common nuclear stain and can be used for the demonstration
f Nissl substance in nerve cells of the CNS. | [Preparation]
The first thiazine dye, named after its dis coverer, was Lauth's Violet, which was obtained in 1876 by joint oxidation of 1,4-phenylenediamine and hydrogen sulfide with iron(III) chloride. | [General Description]
Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects. Thrombin is also known as coagulation factor IIa. It is a serine endopeptidase that hydrolyzes peptide and ester bonds specifically at the carboxylic side of arginine. This enzyme converts fibrinogen to fibrin. |
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