| Identification | More | [Name]
Deslorelin | [CAS]
57773-65-6 | [Synonyms]
DES-GLY10,[D-TRP6]-LH-RH ETHYLAMIDE
(DES-GLY10,D-TRP6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
(DES-GLY10,D-TRP6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE (SEA BREAM)
(DES-GLY10,D-TRP6,PRO-NHET9)-LHRH
[DES-GLY10, D-TRP6, PRO-NHET9]-LH-RH (HUMAN)
(DES-GLY10,D-TRP6,PRO-NHET9)-LHRH (SEA BREAM)
(DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
(DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (SEA BREAM)
(DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
[DES-GLY10, D-TRP6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE HUMAN
(DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE (SEA BREAM)
DESLORELIN
deslorelin acetate
DESLORELIN (HUMAN)
DESORELIN
[D-TRP6, DES-GLY10]-LH-RH ETHYLAMIDE
GLP-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET
PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET
PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET
PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO NHCH2CH3 | [EINECS(EC#)]
637-335-2 | [Molecular Formula]
C64H83N17O12 | [MDL Number]
MFCD00167401 | [Molecular Weight]
1282.45 | [MOL File]
57773-65-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
>189oC | [alpha ]
D24 -61° (c = 0.37 in 0.1M acetic acid) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Acetic acid (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.82±0.15(Predicted) | [color ]
White to Off-White | [Sequence]
Pyr-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-NHEt | [InChIKey]
GJKXGJCSJWBJEZ-QCOVUDKBNA-N | [CAS DataBase Reference]
57773-65-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R60:May impair fertility. | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3
| [RTECS ]
OK6755000
| [HS Code ]
3504009000 |
| Hazard Information | Back Directory | [Description]
Deslorelin is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. | [Chemical Properties]
White powder, tens of times more biologically active than natural LH-RH, is synthesized by solid-phase or liquid-phase synthesis method using the corresponding protected amino acid monomers as raw materials. | [Uses]
Induction of ovulation in estrous mares
Reproduction control in dogs | [Definition]
ChEBI: Deslorelin is an oligopeptide. | [Brand name]
Somagard [as acetate] (Roberts Pharmaceutical). | [General Description]
Deslorelin (brand names: SucroMate, Suprelorin F, Suprelorin 12, Suprelorin-6) is a synthetic hormone used to induce ovulation and manage artificial insemination programs in horses, modulate reproduction in dogs, or manage adrenal disease in ferrets. In the U.S., deslorelin is only FDA approved for use in mares and ferrets, and 'off label' or 'extra-label' use is prohibited at this time. | [Side effects]
The most common side effects include swelling, sensitivity, and redness or warmth at the injection site. Rarely reported side effects in dogs include prolonged estrus and uterine infections. | [Veterinary Drugs and Treatments]
Deslorelin is approved for inducing ovulation in estrual mares.
There is also interest in developing dosages and dosage forms as a
long-term, reversible contraceptive in a variety of animal species, as
a treatment for prostatic disease in male dogs, and incontinence in
ovariectomized dogs. At the time of writing, deslorelin in not available
in the USA, but is marketed in Canada.
In humans, deslorelin has been investigated for treating children
with precocious puberty, and in adults for prostate carcinoma, dysmenorrhea,
fibroids, and endometriosis. | [References]
[1] CLAIRE GROSSET. Contraceptive effect and potential side-effects of deslorelin acetate implants in rats (Rattus norvegicus): preliminary observations.[J]. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2012, 76 3: 209-214.
[2] STEFANO ROMAGNOLI. Chronic Use of Deslorelin in Dogs: Six Cases (2005-2022).[J]. Animals, 2023, 13 2. DOI:10.3390/ani13020265.
[3] K E OERTER. Adult height in precocious puberty after long-term treatment with deslorelin.[J]. Journal of Clinical Endocrinology & Metabolism, 1991, 73 6: 1235-1240. DOI:10.1210/jcem-73-6-1235. |
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