| Identification | More | [Name]
OXAMIC ACID SODIUM SALT | [CAS]
565-73-1 | [Synonyms]
AMINOOXOACETIC ACID SODIUM SALT
OXALIC ACID MONOAMIDE SODIUM SALT
OXAMIC ACID SODIUM SALT
SODIUM OXAMATE
aminooxo-aceticacimonosodiumsalt
oxamic acid sodium
OxamicacidsodiumsaltOxamicacidsodiumsalt
Aminooxoacetic acid sodium salt, Oxalic acid monoamide sodium salt, Oxamic acid sodium salt
2-Amino-2-oxoacetic acid sodium salt | [EINECS(EC#)]
209-290-5 | [Molecular Formula]
C2H2NNaO3 | [MDL Number]
MFCD00044553 | [Molecular Weight]
111.03 | [MOL File]
565-73-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
300 °C | [storage temp. ]
Store at RT. | [solubility ]
PBS (pH 7.2): 10 mg/ml | [form ]
solid | [color ]
White to off-white | [Water Solubility ]
Soluble in water (10 mg/ml). | [Detection Methods]
TIT RATION | [BRN ]
6538153 | [InChI]
InChI=1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1 | [InChIKey]
RQVZIJIQDCGIKI-UHFFFAOYSA-M | [SMILES]
C(=O)(N)C([O-])=O.[Na+] | [CAS DataBase Reference]
565-73-1(CAS DataBase Reference) | [EPA Substance Registry System]
Sodium oxamate (565-73-1) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [F ]
10 | [TSCA ]
Yes | [HS Code ]
29241990 |
| Hazard Information | Back Directory | [Description]
Oxamic acid sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis. Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells. | [Chemical Properties]
white crystalline powder | [Uses]
Oxamic acid sodium salt can be used as an inhibitor of gluconeogenesis useful for anticancer research.
| [Application]
Sodium oxamate, an inhibitor of LDH-C4, prevented the AR induced by lysophosphatidylcholine (LPC) or NADH. Oxamic acid sodium salt is an lactic acid dehydrogenase. Sperm suspension and cytosol fraction activities were inhibited by sodium oxamate. As cancer cells are often dependent on glycolysis for ATP production, sodium oxamate has implications as an anticancer compound. | [Biochem/physiol Actions]
Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes. | [in vitro]
Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells.
Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells.
Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells.
Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells.
Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells. |
|
|