| Identification | More | [Name]
Deoxycorticosterone acetate | [CAS]
56-47-3 | [Synonyms]
11-DEOXYCORTICOSTERONE ACETATE
11-desoxycorticosterone acetate
21-ACETOXY-4-PREGNENE-3,20-DIONE
21-ACETOXYPROGESTERONE
21-HYDROXY-4-PREGNENE-3,20-DIONE 21-ACETATE
21-HYDROXYPROGESTERONE 21-ACETATE
21-HYDROXYPROGESTERONE ACETATE
4-PREGNEN-21-OL-3,20-DIONE 21-ACETATE
4-PREGNEN-21-OL-3,20-DIONE ACETATE
CORTEXONE ACETATE
DELTA4-PREGNEN-21-OL-3, 20-DIONE ACETATE
DEOXYCORTICOSTERONE ACETATE
DESOXYCORTICOSTERONE ACETATE
DESOXYCORTONE ACETATE
DOCA
DOC ACETATE
11-deoxycorticosterone21-acetate
20-dione,21-hydroxy-pregn-4-ene-acetate
21-acetoxy-3,20-diketopregn-4-ene
21-Acetyloxypregn-4-ene-3,20-dione | [EINECS(EC#)]
200-275-9 | [Molecular Formula]
C23H32O4 | [MDL Number]
MFCD00003660 | [Molecular Weight]
372.5 | [MOL File]
56-47-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
157°C | [alpha ]
D20 +168 to +176° (dioxane) | [Boiling point ]
421.94°C (rough estimate) | [density ]
1.0415 (rough estimate) | [refractive index ]
175 ° (C=1, Dioxane) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
H2O: insoluble
| [form ]
neat | [color ]
White to Off-White | [Water Solubility ]
4mg/L(25 ºC) | [Merck ]
2901 | [BRN ]
2570798 | [InChI]
InChI=1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1 | [InChIKey]
VPGRYOFKCNULNK-ACXQXYJUSA-N | [SMILES]
C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@H](C(=O)COC(C)=O)CC3)CC2 | [LogP]
3.080 | [CAS DataBase Reference]
56-47-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 2811 | [WGK Germany ]
3
| [RTECS ]
HG0525000
| [HazardClass ]
IRRITANT | [HS Code ]
2937290000 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Adrenocortical/mineralocorticoid Steroid. | [Definition]
ChEBI: Deoxycorticosterone acetate is a corticosteroid hormone. | [Brand name]
Doca (Organon); Percorten (Novartis) [Name previously used: Deoxycortone.]. | [General Description]
Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one. | [storage]
Store at -20°C | [Purification Methods]
11-Deoxycorticosterone acetate recrystallises from EtOH as needles or Me2CO/hexane, and sublimes at high vacuum. It is partly soluble in MeOH, Me2CO, Et2O and dioxane but insoluble in H2O. [Reichstein & Euw Helv Chim Acta 23 136 1940, Romo et al. J Am Chem Soc 79 5034 1957; NMR: Shoolery & Rogers J Am Chem Soc 80 5121 1959, Beilstein 8 IV 2195.] |
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