| Identification | Back Directory | [Name]
Deoxyarbutin | [CAS]
53936-56-4 | [Synonyms]
Deoxyarbutin
Tetrahydropyranyloxyphenol
4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol
Phenol,4-[(tetrahydro-2H-pyran-2-yl)oxy]-
Deoxyarbutin
4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C11H14O3 | [MDL Number]
MFCD09970981 | [MOL File]
53936-56-4.mol | [Molecular Weight]
194.23 |
| Chemical Properties | Back Directory | [Melting point ]
88-89 °C(Solv: ligroine (8032-32-4)) | [Boiling point ]
349.8±32.0 °C(Predicted) | [density ]
1.174 | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
10.10±0.15(Predicted) | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase).1 It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM.2 Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM).3 It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model. | [Uses]
Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin. | [Preparation]
Deoxyarbutin is a derivative of ?-arbutin, obtained by removal of hydroxyl groups from the glucose side-chain of ?-arbutin.
| [storage]
Store at -20°C |
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