| Identification | More | [Name]
2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE | [CAS]
5381-99-7 | [Synonyms]
2-CHLORO-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
2-CHLORO-4H-1,2,3-BENZODIOXAPHOSPHORIN-4-ONE
2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
SALICYLCHLOROPHOSPHITE
VAN BOOM'S REAGENT
ChloroHbenzodioxaphosphorinone
2-Chloro-4H-1,2,3-benzodioxaphosphorin-4-one 90%
2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE 97% | [Molecular Formula]
C7H4ClO3P | [MDL Number]
MFCD00013353 | [Molecular Weight]
202.53 | [MOL File]
5381-99-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
36-40 °C (lit.) | [Boiling point ]
127-128 °C/11 mmHg (lit.) | [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
Soluble in acetonitrile, dichloromethane, tetrahydrofuron and dimethylformamide. | [form ]
solid | [color ]
White or Colorless to Orange to Green | [Usage]
Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs | [BRN ]
1311951 | [Stability:]
Water Sensitive | [CAS DataBase Reference]
5381-99-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R14:Reacts violently with water.
R34:Causes burns.
R37:Irritating to the respiratory system. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3261 8/PG 1
| [WGK Germany ]
3
| [F ]
3-10 | [Hazard Note ]
Corrosive | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
2-Chloro-1,3,2-benzodioxaphosphorin-4-one is used as a reagent:
- In the phosphorylation and phosphitylation of alcohols.
- In the formation of H-phosphonates which are commonly utilized in the synthesis of nucleotides.
- To synthesize nucleoside triphosphates by treating with acyl protected nucleoside.
| [Uses]
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog. | [Uses]
Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs | [reaction suitability]
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand |
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