| Identification | More | [Name]
Domiphen bromide | [CAS]
538-71-6 | [Synonyms]
(DODECYLDIMETHYL-2-PHENOXYETHYL)-AMMONIUM BROMIDE
DOMIPHEN
DOMIPHEN BROMIDE
LABOTEST-BB LT00847867
beta-phenoxyethyldimethyldodecylammoniumbromide
bradasol
bradonit
bradoral
bradosol
bradosolbromide
dimethyldodecyl(2-phenoxyethyl)-ammoniubromide
dodecyldimethyl(2-phenoxyethyl)-ammoniubromide
dodecyldimethyl(2-phenoxyethyl)-ammoniumbromid
fungitex
fungitexr
n,n-dimethyl-n-(2-phenoxyethyl)-1-dodecanaminiubromide
nsc-39415
oradol
pddb
DOMOPHEN BROMIDE | [EINECS(EC#)]
208-702-0 | [Molecular Formula]
C22H40BrNO | [MDL Number]
MFCD00011769 | [Molecular Weight]
414.46 | [MOL File]
538-71-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
117-119 °C (lit.) | [density ]
1.1411 (rough estimate) | [refractive index ]
1.5570 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
Soluble in ethanol, acetone, ethyl acetate, chloroform and water. Slightly soluble in benzene. | [Sensitive ]
Hygroscopic | [Merck ]
14,3415 | [BRN ]
3922742 | [InChIKey]
OJIYIVCMRYCWSE-UHFFFAOYSA-M | [CAS DataBase Reference]
538-71-6(CAS DataBase Reference) | [EPA Substance Registry System]
538-71-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
BQ2030000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [Safety Profile]
Poison by intraperitoneal
and intravenous routes. hfutauon data reported.
When heated to decomposiuon it emits very toxic
fumes of NOx, NH3, and Br-. See also
BROMIDES. | [Hazardous Substances Data]
538-71-6(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Description]
Domiphen is a quaternary ammonium compound and cationic surfactant with antimicrobial activity.1,2 It is active against A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes bacteria and inhibits C. neoformans yeast growth and spore germination.1,2,3,4 It also inhibits the human-ether-a-go-go-related gene (hERG) channel (IC50 = 1.5 μM in a whole-cell patch-clamp assay).5 Formulations containing domiphen have been used as antiseptics, disinfectants, and biocides in industrial, agricultural, veterinary, and clinical applications. | [Originator]
Bradosol,Ciba,US,1958 | [Uses]
Antiinfective, topical. | [Uses]
Domiphen bromide is employed as a phase transfer catalyst in synthetic chemistry. It is used as a quaternary ammonium cation with cationic surfactant properties. Further, it is used as an antiseptic and an active pharmaceutical ingredient. | [Definition]
ChEBI: Domiphen bromide is an aromatic ether. | [Manufacturing Process]
7 parts of β-phenoxyethyl-dimethylamine are heated for 2 hours on the boiling
water-bath with 11 parts of dodecyl bromide. A good yield of β-phenoxy-ethyldimethyl-dodecyl-ammonium bromide is obtained which, after recrystallization
from acetone, melts at 112°C. It is a white crystalline powder which dissolves
easily in water to give a neutral reaction. | [Therapeutic Function]
Topical antiinfective |
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