| Identification | Back Directory | [Name]
QX 314 chloride | [CAS]
5369-03-9 | [Synonyms]
QX314.Cl
QX 314 CHLORIDE
N-Ethyllidocaine chloride
Lidocaine N-ethyl chloride
QX-314;QX314;N-ETHYLLIDOCAINE CHLORIDE
[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride
N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE
[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride
[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride
2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride | [Molecular Formula]
C16H27ClN2O | [MDL Number]
MFCD01669894 | [MOL File]
5369-03-9.mol | [Molecular Weight]
298.85 |
| Chemical Properties | Back Directory | [Melting point ]
209-211 °C | [storage temp. ]
Room temp | [solubility ]
insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O | [form ]
solid | [color ]
White | [Water Solubility ]
Soluble in water (100mM) |
| Hazard Information | Back Directory | [Uses]
QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.
| [Biological Activity]
Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels. | [Biochem/physiol Actions]
Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker. | [storage]
Store at RT |
|
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