| Identification | More | [Name]
Coumarin 151 | [CAS]
53518-15-3 | [Synonyms]
7-AMINO-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE
7-AMINO-4-TRIFLUOROMETHYL-CHROMEN-2-ONE
7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN
AFC
AKOS B000459
BUTTPARK 20\02-79
COUMARIN 151
7-amino-4-(trifluoromethyl)-2h-1-benzopyran-2-on
7-amino-4-(trifluoromethyl)-2-benzopyrone
Coumarin 490
7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN, FOR FLUORESCENCE
7-AMIDO-4-TRIFLUOROMETHYLCOUMARIN
7-AMINO-4-(TRIFLUOROMETHYL)COUMARIN, 99+ %
Caspase 8 Fluorometric Substrate, IETD-AFC (FLICE, MASH, Mch5, N-acetyl-Asp-Glu-Val-Asp-AFC
Coumarin 151, laser grade, pure, 99%
7-Amino-4-(trifluoromethyl)coumarin 99%
Coumarine151
7-Amino-4-(trifluoromethyl)-2H-1-benzopyran-2-one
Coumarin 490. Coumarin 15
COUMARIN 151, 99%, LASER GRADE, PURE | [EINECS(EC#)]
258-599-1 | [Molecular Formula]
C10H6F3NO2 | [MDL Number]
MFCD00006858 | [Molecular Weight]
229.16 | [MOL File]
53518-15-3.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow powder | [Melting point ]
221-222 °C(lit.) | [Boiling point ]
314.6±42.0 °C(Predicted) | [density ]
1.4096 (estimate) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
Powder | [pka]
1.12±0.20(Predicted) | [color ]
Yellow | [Water Solubility ]
Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water. | [λmax]
≤207 nm | [Detection Methods]
HPLC | [BRN ]
4456797 | [CAS DataBase Reference]
53518-15-3(CAS DataBase Reference) | [EPA Substance Registry System]
53518-15-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
T | [HazardClass ]
IRRITANT | [HS Code ]
29322090 |
| Hazard Information | Back Directory | [Chemical Properties]
Coumarin 151 is yellow powder
| [Uses]
7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye. | [Uses]
Coumarin 151 is used to prepare peptidase substrates and for the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids.
| [Definition]
ChEBI: 7-amino-4-(trifluoromethyl)coumarin is a member of 7-aminocoumarins. It has a role as a fluorochrome. | [Purification Methods]
Purify the coumarin by column chromatography on a C18 column, elute with acetonitrile/0.01M H2O/HCl (1:1), and recrystallise it from isopropanol. Alternatively, it is eluted from a silica gel column with CH2Cl2, or by extracting a CH2Cl2 solution (4g/L) with 1M aqueous NaOH (3 x 0.1L), followed by drying (MgSO4), filtration and evaporation. [Bissell J Org Chem 45 2283 1980, Zimmermann et al. Anal Biochem 70 258 1976.] |
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