| Identification | More | [Name]
Magnolol | [CAS]
528-43-8 | [Synonyms]
5,5'-DIALLYL-2,2'-BIPHENYLDIOL
5,5'-DIALLYL-2,2'-DIHYDROXYBIPHENYL
5,5'-DIALLYL-BIPHENYL-2,2'-DIOL
MAGNOLOL
1’-Biphenyl)-2,2’-diol,5’,5-di-2-propenyl-(1
Magnolia officinalis Rehd.et Wils
MAGNOLOL 98.0% BY HPLC
Honokiol std.
Magnolol std.
HONOKIOL(P)
MAGNOLOL(SH)
5',5-di-2-propenyl-(1,1'-Biphenyl)-2,2'-diol
MAGNOLIABARKEXTRACT
[1,1'-Biphenyl]-2,2'-diol,5,5'-di-2-propenyl-
2,2'-Bichavicol
2,2'-Biphenyldiol, 5,5'-diallyl- | [EINECS(EC#)]
610-903-7 | [Molecular Formula]
C18H18O2 | [MDL Number]
MFCD00016658 | [Molecular Weight]
266.33 | [MOL File]
528-43-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
101.5-102° | [Boiling point ]
180°C/1mmHg(lit.) | [density ]
1.107±0.06 g/cm3(Predicted) | [FEMA ]
4559 | MAGNOLOL | [storage temp. ]
2-8°C | [solubility ]
ethanol: soluble1mg/mL | [form ]
neat | [pka]
9.49±0.43(Predicted) | [color ]
White to Almost white | [Odor]
bitter | [λmax]
292nm(EtOH)(lit.) | [JECFA Number]
2023 | [Merck ]
13,5721 | [Stability:]
Light Sensitive | [LogP]
4.502 (est) | [CAS DataBase Reference]
528-43-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
N | [Risk Statements ]
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 3077 | [WGK Germany ]
3 | [RTECS ]
DV5105500 | [HS Code ]
29072990 | [Hazardous Substances Data]
528-43-8(Hazardous Substances Data) | [Toxicity]
LD50 orl-mus: 2200 mg/kg BRXXAA #5135746 |
| Hazard Information | Back Directory | [Hazard]
Moderately toxic by ingestion. | [Chemical Properties]
White or off-white powder | [Uses]
Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-a-*induced ICAM-1 expression in human lung epithelial cells. | [Definition]
ChEBI: Magnolol is a member of biphenyls. | [Biological Activity]
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively. | [Mechanism of action]
Magnolol (5,5’-diallyl-2,2’-dihydroxybiphenyl) is a polyphenolic binaphthalene compound and a structural isomer of honokiol. Both magnolol and honokiol are isolated from the stem bark of a traditional Chinese herbal medicine Magnolia officinalis, which has been used for management of nervous disturbance, abdominal distention or disorders, gastrointestinal food stagnancy, and coughing and dyspnea. Magnolol has showed a wide spectrum of beneficial activities, including anti-inflammation, antimicroorganism, antioxidation, antiangiogenesis, anticancer, neuroprotection, cardiovascular protection, and lipolysis activities. | [Safety Profile]
Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors. | [in vitro]
Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml. | [in vivo]
Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice. |
| Questions And Answer | Back Directory | [Description]
Magnolol is an organic compound belonging to lignan. It is a kind of
bioactive compounds identified from the bark of the Magnolia
officinalis or M. grandiflora. It has been supplemented to Asian
traditional medicine for the treatment of anxiety, sleep disorders,
and allergic disease. It can act on the GABA receptor in vitro as a
strong allosteric modulator. It also has antifungal effect, anti-
periodontal activity as well as many osteoblast-stimulating and
osteoclast-inhibiting activities. It has also found that magnolol
can also activate the cannabinoid (CB) receptors. | [References]
https://en.wikipedia.org/wiki/Magnolol
https://www.caymanchem.com/product/14233
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