| Identification | More | [Name]
2-Hydroxy-N-(4-hydroxyphenyl)-benzamide | [CAS]
526-18-1 | [Synonyms]
2-hydroxy-n-(4-hydroxyphenyl)-benzamide
LOIRD
N-(4-HYDROXYPHENYL)SALICYLAMIDE
N-SALICYLOYL-P-AMINOPHENOL
OSALMID
2-hydroxy-n-(4-hydroxyphenyl)-benzamid
4’-hydroxy-salicylanilid
4’-hydroxysalicylanilide
4-Hydroxysalicylanilide
auxobil
bilene
bilocol
dribazil
driol
driol-labaz
enidran
hydroxyphenylsalicylamide
l1718
n-(p-hydroxyphenyl)salicylamide
osalmide | [EINECS(EC#)]
208-385-9 | [Molecular Formula]
C13H11NO3 | [MDL Number]
MFCD00020026 | [Molecular Weight]
229.23 | [MOL File]
526-18-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
179° | [Boiling point ]
371.13°C (rough estimate) | [density ]
1.2084 (rough estimate) | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO : ≥ 28 mg/mL (122.15 mM) | [form ]
Solid | [pka]
8.40±0.30(Predicted) | [color ]
White to off-white | [Water Solubility ]
916mg/L at 25℃ | [LogP]
2.47 at 25℃ | [CAS DataBase Reference]
526-18-1(CAS DataBase Reference) | [EPA Substance Registry System]
526-18-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves . | [Toxicity]
LD50 oral in rat: 6702mg/kg |
| Hazard Information | Back Directory | [Definition]
ChEBI: Osalmid is an organic molecular entity. | [Biochem/physiol Actions]
Osalmid is a potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid inhibits RR (ribonucleotide reductase) activity in vivo, and exhibits synergistic effect with lamivudine on inactivation mutant HBV strain. Osalmid is a biliation activator (choleretic agent), but a mechanism of this activity remains unknown. | [storage]
Store at -20°C |
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