| Identification | Back Directory | [Name]
ETHYLHYDROCUPREINE | [CAS]
522-60-1 | [Synonyms]
optochin
numoquin
optoquine
Numoquine
Optochine
Ethylhydrocuprein
ETHYLHYDROCUPREINE
hydrocupreineethylether
6’-ethoxy-hydrocinchonidin
Hydrocupureine ethyl ether
o(sup6’)-ethyl-hydrocuprein
ethylhydrocupreine free base*crystalline
Cinchonan-9-ol,6'-ethoxy-10,11-dihydro-, (8a,9R)-
Cinchonan-9-ol, 6'-ethoxy-10,11-dihydro-, (8α,9R)-
6’-ethoxy-10,11-dihydro-,(8-alpha,9r)-cinchonan-9-o | [EINECS(EC#)]
208-333-5 | [Molecular Formula]
C21H28N2O2 | [MDL Number]
MFCD00135595 | [MOL File]
522-60-1.mol | [Molecular Weight]
340.46 |
| Chemical Properties | Back Directory | [Melting point ]
123-128° when solvent-free | [alpha ]
D25 -136.2° (alcohol) | [Boiling point ]
476.25°C (rough estimate) | [density ]
1.1027 (rough estimate) | [refractive index ]
1.6180 (estimate) | [storage temp. ]
2-8°C
| [form ]
neat |
| Hazard Information | Back Directory | [Uses]
Ethylhydrocupreine is an antibiotic tested against isolates of Streptococcus mitis resulting in an 100% resistance. Also, ethylhydrocupreine susceptibility test is a key method for differentiating Streptococcus pneumoniae from other α-hemolytic streptococci. | [Definition]
ChEBI: A cinchona alkaloid consisting of 10,11-dihydrocinchonan bearing hydroxy and ethoxy substituents at positions 9 and 6' respectively. | [in vivo]
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs[1]. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
| Website: |
www.biorbyt.com |
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