| Identification | More | [Name]
Tetramisole hydrochloride | [CAS]
5086-74-8 | [Synonyms]
(+/-)-2,3,5,6-TETRAHYDRO-6-PHENYLIMIDAZO[2,1-B]THIAZOLE HYDROCHLORIDE
[+/-]-2,3,5,6-TETRAHYDRO-6-PHENYLIMIDAZO[2,1-B]THIAZOLE HYDROCHLORIDE
DL-2,3,5,6-TETRAHYDRO-6-PHENYL-IMIDAZO-[2,1-B]-THIAZOLE HYDROCHLORIDE
TETRAMISOLE HCL
TETRAMISOLE HYDROCHLORIDE
TETRAMISOL HYDROCHLORIDE
(+-)-2,3,5,6-tetrahydro-6-phenylimidazo(2,1-b)thiazolemonohydrochloride
(+-)-anthelvet
1-b)thiazole,2,3,5,6-tetrahydro-6-phenyl-,monohydrochloride,(+-)-imidazo(
anthelvet
bayer9051
citarin
dl-6-phenyl-2,3,5,6-tetrahydroimidazole(2,1-b)thiazole-hydrochloride
dl-tetramisolehydrochloride
mcn-jr-8299
nilverm
nilverom
orovermol
r8299
ripercol | [EINECS(EC#)]
225-799-5 | [Molecular Formula]
C11H13ClN2S | [MDL Number]
MFCD00005536 | [Molecular Weight]
240.75 | [MOL File]
5086-74-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white to pale cream crystalline powder | [Melting point ]
266-267 °C(lit.)
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Methanol (Slightly), Water (Slightly, Heated) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
200 g/L (20 ºC) | [Merck ]
13,5480 | [BRN ]
4358989 | [Stability:]
Hygroscopic | [InChIKey]
LAZPBGZRMVRFKY-UHFFFAOYSA-N | [CAS DataBase Reference]
5086-74-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
NJ5950000
| [HS Code ]
29349990 | [Toxicity]
LD50 in mice, rats (mg/kg): 22, 24 i.v.; 84, 130 s.c.; 210, 480 orally (Thienpoint) |
| Hazard Information | Back Directory | [Chemical Properties]
white to pale cream crystalline powder | [Uses]
Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator. | [Application]
Tetramisole is an alkaline phosphatase inhibitor. It is a racemic mixture of (+) and (-) isomers. The (-) isomer (levamisole) accounts for most of the biological activity of tetramisole.
Tetramisole has been used to inhibit alkaline phosphatase in the effective range of 0.4 – 2 mM. Inhibition of intestinal alkaline phosphate requires higher concentrations. In addition to its use in enzyme and protein phosphorylation studies, tetramisole has been used to study membrane, tissue and animal systems.
Tetramisole is an anthelminthic agent used in veterinary applications to treat helminth or worm infections. | [Definition]
ChEBI: Tetramisole hydrochloride is an organic molecular entity. It is a broad-spectrum veterinary anthelmintic with high efficiency and low toxicity. | [Brand name]
Ergamisol (Janssen). | [in vitro]
Tetramisole hydrochloride at 67.5 mg/kg is 88.8% effective against immature and 99.7% effective against adult Libyostrongylus douglassi of the ostrich. A dose of up to 408 mg/kg tetramisole hydrochloride had no adverse effects on young birds but at 529 mg/kg was lethal to both chicks and adult ostriches. The efficacy of pyrantel tartrate was erratic. At 50 - 60 mg/kg it was 72.3% effective against immatures and 50.2% effective against adult worms. At 100 mg/kg it fell to 43.6% against immature, but rose to 77.3% against adult worms. Pyrantel tartrate at 100 mg/kg caused the death .of three out of four chicks. The macroscopic lesions of the disease ""vrotmaag"" caused by L. douglassi are descriptionbed as well as some of the other pathological lesions observed at autopsy. | [Mode of action]
Tetramisole HCl inhibits parasitic worm growth by acting as an agonist to nicotinic acetylcholine receptors leading to paralysis. The mechanism of action for anticancer activity is unknown. |
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