| Identification | More | [Name]
4-Amino-1-benzylpiperidine | [CAS]
50541-93-0 | [Synonyms]
1-BENZYL-4-AMINOPIPERIDINE
1-BENZYL-4-PIPERIDINAMINE
1-BENZYLPIPERIDIN-4-AMINE
1-BENZYL-PIPERIDIN-4-YLAMINE
4-(1-PIPERIDINYLMETHYL)ANILINE
4-AMINO-1-BENZYLPIPERIDINE
4-AMINO-1-N-BENZYLPIPERIDINE
4-AMINO-1-PHENYLMETHYLPIPERIDINE
4-AMINO-N-BENZYLPIPERIDINE
4-(PIPERIDIN-1-YLMETHYL)ANILINE
4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE
AKOS B014375
AKOS BBS-00006436
AKOS BOR-MOSH-08
AKOS MSC-0180
ART-CHEM-BB B014375
ART-CHEM-BB B016020
ASISCHEM W54645
N-(4-AMINOBENZYL)PIPERIDINE
N-BENZYL-4-AMINO PIPERIDINE | [EINECS(EC#)]
256-620-9 | [Molecular Formula]
C12H18N2 | [MDL Number]
MFCD03422516 | [Molecular Weight]
190.28 | [MOL File]
50541-93-0.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless to light yellow liquid | [Melting point ]
121-122 °C(Solv: water (7732-18-5); ethanol (64-17-5)) | [Boiling point ]
152 °C (9.7 mmHg)
| [density ]
0.933 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.543(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
10g/l | [form ]
Liquid | [pka]
10.15±0.20(Predicted) | [color ]
Clear colorless to light yellow | [PH]
11.4 (10g/l, H2O) | [Water Solubility ]
immiscible | [Sensitive ]
Air Sensitive | [BRN ]
146038 | [InChIKey]
YUBDLZGUSSWQSS-UHFFFAOYSA-N | [CAS DataBase Reference]
50541-93-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
8-10-34 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29333999 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colourless to light yellow liquid | [Uses]
4-Amino-1-benzylpiperidine was used in the preparation of:
- butyl 4-amino-1-piperidineacetate, key intermediate required for the synthesis of butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate
- 5-alkylimino-1,2,4-thiadiazolidine-3-ones, such as 4-ethyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-methyl-1,2,4-thiadiazolidin-3-one and 4-benzyl-5-[imino-[1-(phenylmethyl)-4-piperidinyl]]-2-isopropyl-1,2,4-thiadiazolidin-3-one
- glycyrrhetinic acid derivatives
| [Purification Methods]
Purify it by distillation in vacuo and store it under N2 because it absorbs CO2. The dihydrochloride salt [1205-72-7] has m 270-273o (255o) after recrystallisation from MeOH/EtOAc or EtOH. [Brookes J Chem Soc 3165, 3172 1957.] The 4-methylamino-1-benzylpiperidine derivative has b 168-172o/17mm, nD 1.5367 [Reitsema & Hunter J Am Chem Soc 70 4009 1948]. The 1-(1-benzyl-4-piperidinyl)-3-cyano-2-methylisothiourea derivative has m 160o from CHCl3/Et2O [Preparation, IR, NMR: Ried et al. Chem Ber 116 1547 1983, Beilstein 22 III/IV 3752]. |
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