| Identification | More | [Name]
4-Fluorobenzyl bromide | [CAS]
459-46-1 | [Synonyms]
1-(BROMOMETHYL)-4-FLUOROBENZENE
4-FLUOROBENZYL BROMIDE
ALPHA-BROMO-4-FLUOROTOLUENE
ALPHA-BROMO-P-FLUOROTOLUENE
P-FLUOROBENZYL BROMIDE
1-(bromomethyl)-4-fluoro-benzen
Benzene, 1-(bromomethyl)-4-fluoro-
Toluene, alpha-bromo-p-fluoro-
4-fluoro(bromomethyl)benzene
1-bromo-3-fluorotoluene
4-Fluorobenzyl Bromide p-Fluorobenzyl Bromide
4-FLUOROBENZYL BROMIDE 98% (GC)
4-Fluorobenzylbromide,97%
à-bromo-4-fluorotoluene
4-Fluorobenzyl bromide 90%
4-FLUOROBBENZYL BROMIDE
A-BROMO-4-FLUOROTOLUENE
α-Bromo-4-fluorotoluene, 1-Bromomethyl-4-fluorobenzene
4-Fluorobenzyl bromide ,98%
4-Fluoro-1-(bromomethyl)benzene | [EINECS(EC#)]
207-291-5 | [Molecular Formula]
C7H6BrF | [MDL Number]
MFCD00000359 | [Molecular Weight]
189.02 | [MOL File]
459-46-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Boiling point ]
85 °C15 mm Hg(lit.)
| [density ]
1.517 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.547(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
soluble in Chloroform | [form ]
Liquid | [color ]
Clear colorless to yellow | [Specific Gravity]
1.517 | [Sensitive ]
Lachrymatory | [Detection Methods]
GC | [BRN ]
636507 | [InChIKey]
NVNPLEPBDPJYRZ-UHFFFAOYSA-N | [CAS DataBase Reference]
459-46-1(CAS DataBase Reference) | [NIST Chemistry Reference]
«alpha»-Bromo-4-fluorotoluene(459-46-1) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
459-46-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Corrosive/Lachrymatory | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29039900 |
| Questions And Answer | Back Directory | [Chemical Properties]
4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.
| [Uses]
4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.
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