| Identification | Back Directory | [Name]
7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide | [CAS]
442666-98-0 | [Synonyms]
Anguizole
7-(Chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
Pyrazolo[1,5-a]pyrimidine-2-carboxamide, 7-(chlorodifluoromethyl)-5-(2-furanyl)-N-(2-thienylmethyl)- | [Molecular Formula]
C17H11ClF2N4O2S | [MDL Number]
MFCD03308216 | [MOL File]
442666-98-0.mol | [Molecular Weight]
408.81 |
| Chemical Properties | Back Directory | [density ]
1.59 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Powder | [pka]
9.14±0.46(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
anguizole is a selective inhibitor of ns4b with ic50 value of 310 nm [1].ns4b (nonstructural protein 4b) is a viral protein which was found in hepatitis c virus and was a key regulator in hcv replication complex formation. it is reported that ns4b plays a pivotal role in hcv replication via inducing a specific membrane rearrangement and designating membranous web. ns4b-ah2, comprising amino acid 42 to 66, is identified as a major regulator for ns4b oligomerization [2].anguizole is a potent ns4b inhibitor and targets the second amphipathic helix of ns4b (ns4b-ah2). when tested with hcv virus, anguizole treatment significantly disrupted ns4b-ah2-mediated biological functions of ns4b which played an important role in hcv life cycle [3]. in huh7.5 cells transferring a plasmid expressing ns4b fused in frame with gfp, 5μm anguizole treatment (48 hours) altered the distribution of ns4b maf pattern which inhibited hcv life cycle [1]. | [target]
HCV | [References]
[1]. bryson, p.d., et al., a small molecule inhibits hcv replication and alters ns4b's subcellular distribution. antiviral res, 2010. 87(1): p. 1-8.
[2]. gouttenoire, j., et al., aminoterminal amphipathic alpha-helix ah1 of hepatitis c virus nonstructural protein 4b possesses a dual role in rna replication and virus production. plos pathog, 2014. 10(10): p. e1004501.
[3]. choi, m., et al., a hepatitis c virus ns4b inhibitor suppresses viral genome replication by disrupting ns4b's dimerization/multimerization as well as its interaction with ns5a. virus genes, 2013. 47(3): p. 395-407. |
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