成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->42864-78-8

42864-78-8

42864-78-8 Structure

42864-78-8 Structure
IdentificationBack Directory
[Name]

Bevantolol hydrochloride
[CAS]

42864-78-8
[Synonyms]

CI 775
Cl 775
Vantol
NC 1400
Ranestol
Sentiloc
BEVANTOLOL HCL
NC-1400 hydrochloride
bevantolol hydrochloride
Bevantolol hydrochloride 1-5 g
Bevantolol hydrochloride, >=99%
Bevantolol hydrochloride USP/EP/BP
BEVANTOLOLHYDROCHLORIDE(FORR&DONLY)
DiMethoxyphenethyl)aMino]-3-(M-tolyloxy)-2-propanol Hydrochloride
1-((3,4-DiMethoxyphenethyl)aMino)-3-(M-tolyloxy)propan-2-ol hydrochloride
1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol hydrochloride
1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanol hydrochloride
2-PROPANOL, 1-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]AMINO]-3-(3-METHYLPHENOXY)-, HYDROCHLORIDE
[Molecular Formula]

C20H28ClNO4
[MDL Number]

MFCD00941389
[MOL File]

42864-78-8.mol
[Molecular Weight]

381.89
Chemical PropertiesBack Directory
[Melting point ]

137-138°
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

White to Off-White
[Merck ]

14,1192
[CAS DataBase Reference]

42864-78-8
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Uses]

Bevantolol is a cardioselective β-adrenergic blocker. Bevantolol is used as an antianginal, antihypertensive, antiarrhythmic.
[Definition]

ChEBI: The hydrochloride salt of bevantolol.
[Brand name]

Vantol (Parke-Davis).
[Hazard]

Moderately toxic by ingestion.
[Description]

Bevantolol hydrochloride is a cardioselective (β1) adrenergic blocker, devoid of intrinsic sympathomimetic and local anesthetic activities. As with other agents of this category, it is useful in the treatment of hypertension and angina.
[Originator]

Warner-Lambert (USA)
[Manufacturing Process]

To a solution of 50 g (1.25 mol) of NaOH in 1200 ml H2O was added 108 g (1 mol) of m-cresol freshly distilled and at 15°C in one lot 117ml (1.5 mol) of epichlorohydrin. The emulsion was stirred at room temperature for 16 hours in a creased flask. The product was taken up in 1000 ml of toluene and washed with 500 ml water. Distillation yielded 135.7 g=82% of 3-(m-tolyloxy)-1,2- epoxypropane, b.p. 61°C at 0.05 mm.
Preparation of bevantolol hydrochloride:
To a suitable reactor under a nitrogen blanket is added 13.7 kg of β-(3,4- dimethoxyphenyl)ethylamine. The amine is cooled to 5°C and 12.5 kg of 3- (m-tolyloxy)-1,2-epoxypropane is added maintaining the temperature between 5-10°C. After 10 hours, the mixture is seeded with bevantolol free base; seeding is repeated approximately every 2 hours until it is evident that crystallization has started. After stirring for 48 hours at 10°C, 26 L of hexane is added. The temperature is raised to 25°C and stirring is continued for 48 hours. The slurry is filtered and the collected solid is dried under vacuum. The product is dissolved in 60 L of isopropyl alcohol and the solution is filtered. The reactor and filter are rinsed with 186 L of isopropyl alcohol and 2.7 kg of anhydrous hydrogen chloride is added to the combined filtrate. The batch is heated to reflux for 2 hours. The temperature is adjusted to 65°C and the solution is seeded with bevantolol hydrochloride crystals. The mixture is held at this temperature with stirring until a heavy sand-like slurry is present. The mixture is allowed to cool to ambient temperature without stirring or artificial cooling. It is then cooled to 20°C. The slurry is centrifuged and the product rinsed with isopropyl alcohol until the filtrate is colorless. After being vacuum dried at 50-55°C the product is milled if necessary; yield of bevantolol hydrochloride 22.7 kg (78.6%); melting point 137-138°C.
[Therapeutic Function]

Antiarrhythmic, Beta-adrenergic blocker
[Safety Profile]

A poison by intraperitoneal andintravenous route. Moderately toxic by ingestion. Whenheated to decomposition it emits toxic vapors of NOx,HCl, and Cl-.
[storage]

Store at -20°C
Safety DataBack Directory
[HS Code ]

2922.19.0900
[Toxicity]

LD50 orl-rat: 460 mg/kg IYKEDH 26,364,1995
Spectrum DetailBack Directory
[Spectrum Detail]

Bevantolol hydrochloride(42864-78-8)1HNMR
42864-78-8 suppliers list
Company Name: Hebei Weibang Biotechnology Co., Ltd
Tel: +8615531157085 , +8615531157085
Website: www.weibangbio.com/
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +86 13288715578 +8613288715578 , +8613288715578
Website: http://www.mojinchemical.com
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: www.bocsci.com/
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418671 +8618949823763 , +8618949823763
Website: www.tnjchem.com
Company Name: ANHUI WITOP BIOTECH CO., LTD
Tel: +8615255079626 , +8615255079626
Website: m.is0513.com/showsupplierproductslist418627/0_en.htm
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167 , +86-18192503167
Website: www.dideu.com
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: 571-88938639 +8617705817739 , +8617705817739
Website: https://www.dycnchem.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490 , +8618058761490
Website: https://www.gihichemicals.com/
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Henan Fengda Chemical Co., Ltd
Tel: +86-371-86557731 +86-13613820652 , +86-13613820652
Website: http://www.fdachem.com
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
Tel: +undefined18621343501 , +undefined18621343501
Website: www.acmec.com.cn/
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Tags:42864-78-8 Related Product Information
119413-54-6 628-13-7 66-84-2 593-56-6 64-17-5 141-78-6 140-88-5 81161-17-3 122-84-9 318-98-9 71-23-8 63659-19-8 6843-66-9 109-94-4 554-68-7 120-47-8