| Identification | More | [Name]
Fenofibric acid | [CAS]
42017-89-0 | [Synonyms]
2-[4-(4-CHLOROBENZOYL) PHENOXY]-2'-METHYL PROPANOIC ACID
2-[4-(4-CHLOROBENZOYL)PHENOXY]-2-METHYLPROPANOIC ACID
2-[4-(4-CHLORO-BENZOYL)-PHENOXY]-2-METHYL-PROPIONIC ACID
FENOFIBRIC ACID
LABOTEST-BB LT00239222
SALOR-INT L498335-1EA
2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-propanoicaci
alpha1081
lf153
lf178acid
procetofenicacid
2-[4-(4-CHLORO-BENZOYL)-PHENOXY]-2-METHYL-PROPIONIC ACID (FENOFIBRIC ACID)
2-[4-(4-CHLOROBENBONYZOYL)PHENOXY)-2-METHYLPROPIONIC ACID
2-[4'-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid
FENOFIBRATE ACID
A-1081 | [EINECS(EC#)]
255-626-9 | [Molecular Formula]
C17H15ClO4 | [MDL Number]
MFCD00792461 | [Molecular Weight]
318.75 | [MOL File]
42017-89-0.mol |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Solid | [Melting point ]
177-179°C | [Boiling point ]
486.5±35.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
powder | [pka]
3.09±0.10(Predicted) | [color ]
White to Off-White | [Usage]
Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-Iediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptorependent manner | [BRN ]
2058973 | [InChI]
InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21) | [InChIKey]
MQOBSOSZFYZQOK-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C(OC1=CC=C(C(=O)C2=CC=C(Cl)C=C2)C=C1)(C)C | [CAS DataBase Reference]
42017-89-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3 | [RTECS ]
UA2453000 | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29189900 | [Toxicity]
LD50 oral in rat: 1242mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
DPP4 inhibitor, antidiabetic | [Uses]
Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-Iediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptorependent manner | [Uses]
Fenofibric acid, the active metabolite of fenofibrate. Increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor–dependent manner. | [Definition]
ChEBI: A monocarboxylic acid that is 2-methylpropanoic acid substituted by a 4-(4-chlorobenzoyl)phenoxy group at position 2. It is a metabolite of the drug fenofibrate. | [Metabolism]
Fenofibric acid is primarily conjugated with glucuronic acid and then excreted in urine. A small amount of fenofibric acid is reduced at the carbonyl moiety to a benzhydrol metabolite, which is, in turn, conjugated with glucuronic acid and excreted in urine. In vitro and in vivo metabolism data indicate that fenofibric acid does not undergo oxidative metabolism (e.g. cytochrome P450) to a significant extent. The enzymes CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 do not play a role in the metabolism of fenofibric acid. |
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