| Identification | Back Directory | [Name]
1-(4-Isobutylphenyl)ethanol | [CAS]
40150-92-3 | [Synonyms]
IBUPROFEN IMP D2
Ibuprofen Impurity 32
Ibuprofen IMpurity-Q(EP/BP)
α-(4-Isobutylphenyl)ethanol
1-(4-ISOBUTYLPHENYL)ETHANOL
α-(4-Isobutylphenyl)ethanol
alpha-(4-Isobutylphenyl)ethanol
(1-HYDROXYETHYL)-4-ISOBUTYLBENZENE
1-[4-(2-methylpropyl)phenyl]ethanol
1-[4-(2-METHYLPROPYL)PHENYL]ETHAN-1-OL
α-Methyl-4-(2-Methylpropyl)benzeneMethanol
(1-HYDROXYETHYL)-4-(2-METHYLPROPYL)BENZENE
Benzenemethanol, α-methyl-4-(2-methylpropyl)-
Ibuprofen impurity 11/α-(4-Isobutylphenyl)ethanol
Ibuprofen Impurity 3 (1-(4-Isobutylphenyl)Ethanol)
Ibuprofen - In house impurity/(1-Hydroxyethyl)-4-(2-methylpropyl)benzene | [EINECS(EC#)]
641-487-5 | [Molecular Formula]
C12H18O | [MDL Number]
MFCD08275597 | [MOL File]
40150-92-3.mol | [Molecular Weight]
178.27 |
| Hazard Information | Back Directory | [Uses]
1-(4-Isobutylphenyl)ethanol is a photodegradation product of Ibuprofen (I140000). Shows cytotoxicity activity. | [Preparation]
1-(4-Isobutylphenyl)ethanol synthesis: A solution of p-isobutylacetophenone (1.20mL), methanol (3.00mL), and sodium borohydride (0.2509g) was mixed in a separatory funnel and allowed to sit for 10min. After the standing time period, a 10 % HCl solution (10.0 mL) was added to remove any unreacted sodium borohydride, and the product was extracted using petroleum ether. 1-(4-Isobutylphenyl)ethanol product (1.002g, 87.2%) was collected and dried using anhydrous sodium sulfate.
1HNMR (300MHz, CDCl3): δ7.281 (2H, m, J = 4.0 Hz), δ7.174 (2H, m, J = 4.0 Hz), δ4.855 (1H, s, J =0.92Hz), δ2.714 (3H, q, J =2.2Hz), δ2.554 (2H, t, J = 2.8 Hz), δ1.795 (1H, q, J = 2.7 Hz), δ1.484 (1H, m, J =2.8Hz), δ0.976 (6H, q, J =6.1Hz). 13C NMR (300 MHz, CDCl3): 143.325, 140.684, 129.143, 125.357, 70.034, 45.196, 30.343, 25.076, 22.725, 22.465. |
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