| Identification | More | [Name]
Chloroacetic acid sodium salt | [CAS]
3926-62-3 | [Synonyms]
CHLOROACETIC ACID MONOSODIUM SALT
CHLOROACETIC ACID SODIUM SALT
SODIUM CHLOROACETATE
SODIUM MONOCHLORACETATE
SODIUM MONOCHLOROACETATE
Aceticacid,chloro-,sodiumsalt
chloro-aceticacisodiumsalt
chloroctansodny
dowdefoliant
monoxone
sma
smca
Sodum chloroacetate
Monochloroacetic Acid Sodium
SodiumChloroacetate,>96%
Sodiumchloroacetate,98%
Natriumchloracetat
Sodium salt of chloroacetic acid
Chloroacetate sodium
sodium salt of chloroacetic acid sodium chloroacetate | [EINECS(EC#)]
223-498-3 | [Molecular Formula]
C2H2ClNaO2 | [MDL Number]
MFCD00002684 | [Molecular Weight]
116.48 | [MOL File]
3926-62-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
199 °C (dec.)(lit.)
| [density ]
1.87[at 20℃] | [vapor pressure ]
0.001Pa at 20℃ | [Fp ]
270°C | [storage temp. ]
-20°C | [solubility ]
820g/l | [form ]
Crystalline Powder | [color ]
White | [PH]
4.5-9.0 (50g/l, H2O, 20℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
440 g/L (20 ºC) | [Sensitive ]
Hygroscopic | [Merck ]
14,2112 | [BRN ]
3597157 | [LogP]
-3.8 at 20℃ | [Uses]
Manufacture of weed killers, dyes, vitamins,
pharmaceuticals; also a defoliant.
| [CAS DataBase Reference]
3926-62-3(CAS DataBase Reference) | [EPA Substance Registry System]
3926-62-3(EPA Substance) |
| Questions And Answer | Back Directory | [description]
Sodium chloroacetate is a white colored powdered solid. It is soluble in water. It may be toxic ingestion or inhalation. It is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.
In one study systemic effects to Sprague-Dawley rats (M/F, numbers per group not indicated) given single doses of sodium chloroacetate at 94, 282, or 470 mg/kg bw demonstrated increased sodium concentration in urine, increased potassium concentration in plasma, and reduced glutathione level in the liver at the highest dose; 2/3 of males died within 24 hours of treatment in the middle and high dose groups. | [Stability and Reactivity:]
Sodium chloroacetate is stable at normal temperatures and pressures. Incompatible with oxidizing agents, reducing agents. | [HUMAN USE AND EXPERIENCE]
There are a number of case studies of the parent compound, monochloroacetic acid (MCA), involving corrosion of skin and eyes and fatalities related to skin absorption of toxicologically significant amounts of MCA and a health-based target concentration of 0.1 mg/L was calculated for MCA in drinking water although Health Canada and Environment Canada have categorized MCA as not entering the environment at levels that may be hazardous to human health. There are, however, no similar data or epidemiological reports for sodium chloroacetate. | [Metabolism/Pharmacokinetics]
After absorption, monochloroacetic acid (parent compound CAS 79-11-8) is converted to thiodiacetic acid and glycolic acid and is accumulated in the liver and kidneys of rats.Metabolism of sodium monochloroacetate is expected to have a similar pharmacokinetic profile. |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
R25:Toxic if swallowed.
R38:Irritating to the skin.
R50:Very Toxic to aquatic organisms. | [Safety Statements ]
S22:Do not breathe dust .
S37:Wear suitable gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2659 6.1/PG 3
| [WGK Germany ]
2
| [RTECS ]
AG1400000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29154000 | [Safety Profile]
Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Cland NazO. Used as an herbicide | [Toxicity]
LD50 orally in Rabbit: 95 mg/kg LD50 dermal Rat > 2000 mg/kg |
| Hazard Information | Back Directory | [General Description]
SODIUM CHLOROACETATE(3926-62-3) is a white colored powdered solid. SODIUM CHLOROACETATE(3926-62-3) is soluble in water. SODIUM CHLOROACETATE(3926-62-3) may be toxic ingestion or inhalation. SODIUM CHLOROACETATE(3926-62-3) is used to make weed killers, dyes and pharmaceuticals. | [Reactivity Profile]
Salts, basic, such as SODIUM CHLOROACETATE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. | [Air & Water Reactions]
SODIUM CHLOROACETATE is soluble in water. | [Health Hazard]
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Fire Hazard]
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways. | [Chemical Properties]
Sodium chloroacetate is a white crystalline powder. It is soluble in water. It may be toxic ingestion or inhalation.
Sodium chloroacetate is a reactive and toxic material, so it is hydrolyzed to glycolic acid nearly quantitatively at the end of the production cycle. Chloroacetic acid always contains traces of dichloroacetic acid, a toxic and unreactive material that appears on the California Prop.65 list. | [Flammability and Explosibility]
Nonflammable | [Biochem/physiol Actions]
Actin plays an important role in cell motility, structure and integrity. Smooth muscle actin-α (SMA)/ α2-smooth muscle actin (ACTA2) interacts with β-myosin heavy chain and helps in vascular smooth muscle cell contraction. The encoded protein modulates the expression of c-MET (tyrosine-protein kinase Met) and focal adhesion kinase (FAK) in human lung adenocarcinoma cells, which positively and selectively mediates tumor progression. Mutation in the gene expression leads to thoracic aortic aneurysms and dissections (TAAD). |
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