Identification | More | [Name]
Lithium triisobutylhydroborate | [CAS]
38721-52-7 | [Synonyms]
LITHIUM TRIISOBUTYLHYDROBORATE LITHIUM TRI-S-BUTYLHYDROBORATE LITHIUM TRI-SEC-BUTYLBOROHYDRIDE LITHIUM TRI-SEC-BUTYLHYDRIDOBORATE L-SELECTRIDE(R) lithium,(beta-4)-borate(1-hydrotris(1-methylpropyl)- lithiumtri-sec-butylborohydride,calselect?li, lithiumtri-sec-butylborohydride,calselect?li,intetrahydrofuran lithium tri-sec-butylhydroborate Lithiumbutylborohydride L-selectride Lithium tri-sec-butylborohydride, in tetrahydrofuran, 1M solution LITHIUM TRI-SEC-BUTYLBOROHYDRIDE SOL. LITHIUM TRI-SEC-BUTYLBOROHYDRIDE SOL., 1 M IN THF A 800 ML L-SELECTRIDE, 1.0M SOLUTION IN TETRAHYDR OFURAN 1.0MinTHF 1.0MsolutioninTHF Lithium tri-sec-butylborohydride, 1M solution in THF Borate(1-), hydrotris(1-methylpropyl)-, lithium, (T-4)- lithium tri-sec-butylborohydride solution | [EINECS(EC#)]
254-101-1 | [Molecular Formula]
C12H28BLi | [MDL Number]
MFCD00011708 | [Molecular Weight]
190.1 | [MOL File]
38721-52-7.mol |
Questions And Answer | Back Directory | [Description]
Lithium tri-sec-butylborohydride, commercially available as a one molar solution in tetrahydrofuran. It is widely used as a mild and strong reducing agent with high stereoselectivity in organic synthesis. | [Features]
Lithium tri-sec-butylborohydride is a new type of hydride reducing agent, which has the characteristics of strong reducing ability and high regio- and stereoselectivity. | [Preparation]
Lithium triisobutylhydroborate can be prepared by:In a 3000ml three-necked flask, add 1000ml of 1mol/L tri-sec-butylboron tetrahydrofuran solution, add 1000ml of 1mol/L triethylenediamine tetrahydrofuran solution simultaneously, introduce nitrogen to start stirring, put the mixture of the two in an ice-water bath After cooling to 0° C., 1000 ml of a 1 mol/L lithium aluminum hydride solution in tetrahydrofuran was slowly added dropwise to the above mixed solution with a constant pressure funnel for about 10 hours. |
Safety Data | Back Directory | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable. R14/15:Reacts violently with water, liberating extremely flammable gases . R17:Spontaneously flammable in air. R34:Causes burns. R35:Causes severe burns. R19:May form explosive peroxides. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S7/8:Keep container tightly closed and dry . S30:Never add water to this product . | [RIDADR ]
UN 3394 4.2/PG 1
| [WGK Germany ]
1
| [F ]
10 | [TSCA ]
Yes | [HazardClass ]
4.3 | [PackingGroup ]
II | [HS Code ]
29319090 |
Hazard Information | Back Directory | [Physical properties]
clear colourless solution | [Uses]
Lithium triisobutylhydroborate is used as a reducing agent. Reagent for: Enantioselective synthesis of a-amino acids via reduction of N-tert-butanesulfinyl ketimine esters. Diastereoselective reduction reactions. Hydride reduction of the Danishefsky pyranones. Asymmetric reductive aldol reaction of enones with a-alkoxy aldehydes. Synthesis of alkanols by carbonylation reactions. | [Uses]
L-Selectride Solution is a reducing agent which is used in the preparation of oxygen heterocycles. Used also as a reactant in the synthesis of novel bicicyclo[3.1.0]hexane analags which may prove useful in the treatment of depression. |
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