| Identification | More | [Name]
7-Fluoroindole | [CAS]
387-44-0 | [Synonyms]
7-FLUORO-1H-INDOLE
7-FLUOROINDOLE
BUTTPARK 24\07-35
7-ETHOXYINDOLE
1H-Indole, 7-fluoro- | [EINECS(EC#)]
640-248-2 | [Molecular Formula]
C8H6FN | [MDL Number]
MFCD01074502 | [Molecular Weight]
135.14 | [MOL File]
387-44-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
61 °C | [Boiling point ]
258.0±13.0 °C(Predicted) | [density ]
1.273±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in methanol. (almost transparency) | [form ]
powder to crystal | [pka]
15.55±0.30(Predicted) | [color ]
White to Light yellow to Light orange | [BRN ]
114740 | [InChIKey]
XONKJZDHGCMRRF-UHFFFAOYSA-N | [CAS DataBase Reference]
387-44-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Brown solid | [Uses]
7-Fluoroindole is a reagent used in chemical synthesis. It has been used to synthesize antiviral compounds against Pseudomonas aeruginosa and Staphylococcus aureus along with creation of immunomodulators.
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. | [Antimicrobial activity]
7-fluoroindole (7FI) was identified as a compound that inhibits biofilm formation and blood hemolysis without inhibiting the growth of planktonic P. aeruginosa cells. Moreover, 7FI markedly reduced the production of quorum-sensing (QS)-regulated virulence factors 2-heptyl-3-hydroxy-4(1H)-quinolone, pyocyanin, rhamnolipid, two siderophores, pyoverdine and pyochelin. 7FI clearly suppressed swarming motility, protease activity and the production of a polymeric matrix in P. aeruginosa. However, unlike natural indole compounds, synthetic 7FI did not increase antibiotic resistance. Therefore, 7FI is a potential candidate for use in an antivirulence approach against persistent P. aeruginosa infection. |
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