| Identification | More | [Name]
2-CHLORO-2,2-DIFLUOROACETOPHENONE | [CAS]
384-67-8 | [Synonyms]
2-CHLORO-2,2-DIFLUOROACETOPHENONE
A-CHLORO-A,A-DIFLUOROACETOPHENONE
ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE
CHLORODIFLUOROACETOPHENONE
alpha,alpha-Difluorophenacyl chloride
à,à-difluorophenacyl chloride
à-chloro-à,à-difluoroacetophene
2-Chloro-2,2-difluoroacetophenone 97%
2-Chloro-2,2-difluoroacetophenone97%
2-CHLORO-2,2-DIFLUOROACETOPHENE, 96%
1-Phenyl-2,2-difluoro-2-chloroethanone
Phenyl(chlorodifluoromethyl) ketone
α,α-Difluoro-α-chloroacetophenone | [EINECS(EC#)]
621-031-1 | [Molecular Formula]
C8H5ClF2O | [MDL Number]
MFCD00042123 | [Molecular Weight]
190.57 | [MOL File]
384-67-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
102-103 °C | [Boiling point ]
94-96 °C35 mm Hg(lit.) | [density ]
1.293 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.497(lit.)
| [Fp ]
163 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Difficult to mix. | [form ]
liquid | [color ]
Clear, colourless | [BRN ]
2251448 | [CAS DataBase Reference]
384-67-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 3334 | [WGK Germany ]
3
| [F ]
19 | [Hazard Note ]
Irritant | [HS Code ]
29147000 |
| Hazard Information | Back Directory | [Description]
Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and
N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to
produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally
diverse phenol derivatives and N-heterocyclic compounds. | [Uses]
2-Chloro-2,2-difluoroacetophenone can be used:
- As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
- As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
- As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
| [General Description]
2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds. | [reaction suitability]
reaction type: C-C Bond Formation |
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