| Identification | More | [Name]
2-Fluorophenol | [CAS]
367-12-4 | [Synonyms]
2-FLUOROHYDROXYBENZENE
2-FLUOROPHENOL
O-FLUOROPHENOL
1-Fluoro-2-hydroxybenzene
2-fluoro-pheno
2-Hydroxyfluorobenzene
o-fluoro-pheno
Phenol, o-fluoro-
Fluorophenolmincolorlessliq
o-Fluorophenol 2-Fluorophenol
2-FLUOROPHENOL, 1000MG, NEAT
2-FLUOROPHENOL 98% (GC)
2-Fluorophenol,98%
1-Bromo-3-fluorobezene
o-Fluorophenol,min.98%
Phenol, 2-fluoro-
2-Fluorophenol99%
2-Fluorophenol (95-98%)
2-Flurophenol
2-Fluorophenol f | [EINECS(EC#)]
206-681-2 | [Molecular Formula]
C6H5FO | [MDL Number]
MFCD00002155 | [Molecular Weight]
112.1 | [MOL File]
367-12-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colourless to yellow liquid | [Melting point ]
16.1 °C (lit.) | [Boiling point ]
171-172 °C/741 mmHg (lit.) | [density ]
1.256 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.511(lit.)
| [Fp ]
116 °F
| [storage temp. ]
Flammables area | [solubility ]
37.7g/l | [form ]
Liquid | [pka]
8.73(at 25℃) | [color ]
Clear colorless to light yellow-brownish | [Specific Gravity]
1.256 | [Stability:]
Stable. Flammable. Incompatible with strong oxidizing agents. | [Water Solubility ]
80.72g/L(25 ºC) | [BRN ]
1905112 | [InChIKey]
HFHFGHLXUCOHLN-UHFFFAOYSA-N | [CAS DataBase Reference]
367-12-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Phenol, 2-fluoro-(367-12-4) | [EPA Substance Registry System]
367-12-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,F,C,Xi,T | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R10:Flammable.
R63:Possible risk of harm to the unborn child.
R43:May cause sensitization by skin contact.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R45:May cause cancer. | [Safety Statements ]
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking .
S24/25:Avoid contact with skin and eyes .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S53:Avoid exposure-obtain special instruction before use .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [RTECS ]
SL4530000
| [Hazard Note ]
Flammable/Corrosive | [TSCA ]
T | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29081000 |
| Hazard Information | Back Directory | [General Description]
Liquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g/cm3. | [Reactivity Profile]
2-FLUOROPHENOL(367-12-4) reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid. | [Air & Water Reactions]
Highly flammable. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: Toxic and irritant. | [Chemical Properties]
Clear colourless to yellow liquid | [Uses]
2-Fluorophenol is a competitive inhibitor in the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA), a catecholamine precursor that is used as a therapeutic agent for patients with ParkinsonтАЩs disease. 2-Fluorophenol is also used as a sole carbon energy source for bacteria. | [Synthesis Reference(s)]
Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015 | [Purification Methods]
Pass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.] |
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