| Identification | Back Directory | [Name]
FHPI HCL | [CAS]
350228-36-3 | [Synonyms]
FHPI HCL
SB202190 HCL
SB 202190, HYDROCHLORIDE
SB 202190 monohydrochloride hydrate
SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem
4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)-1H-IMIDAZOLE HCL
4-(4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1h-imidazol-2-yl)phenol hydrochloride
4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)-1H-IMIDAZOLE HYDROCHLORIDE
4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-iMidazol-2-yl]phenol Monohydrochloride
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate | [Molecular Formula]
C20H15ClFN3O | [MDL Number]
MFCD01862621 | [MOL File]
350228-36-3.mol | [Molecular Weight]
367.8 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: ≥12mg/mL | [form ]
solid | [color ]
white to beige | [Water Solubility ]
water: 0.5mg/mL (slightly soluble)
DMSO: soluble |
| Hazard Information | Back Directory | [Uses]
The water soluble form of SB 202190, a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in high
er levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat. | [Uses]
The water soluble form of SB 202190, a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in higher levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat. | [General Description]
A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388). | [Biochem/physiol Actions]
SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines. |
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