| Identification | Back Directory | [Name]
JX401 | [CAS]
349087-34-9 | [Synonyms]
JX401
p38 MAP Kinase Inhibitor VI, JX401
1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine
1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem
Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]- | [Molecular Formula]
C21H25NO2S | [MDL Number]
MFCD02038777 | [MOL File]
349087-34-9.mol | [Molecular Weight]
355.49 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at RT | [solubility ]
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml). | [form ]
Off-white solid | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM. | [Uses]
JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical] | [Uses]
JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes. | [Definition]
ChEBI:[2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides. | [Biological Activity]
Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture. | [storage]
Store at RT | [References]
1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395. |
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