| Identification | More | [Name]
(1S,2S)-(+)-Pseudoephedrine hydrochloride | [CAS]
345-78-8 | [Synonyms]
(1S,2S)-2-(METHYLAMINO)-1-PHENYL-1-PROPANOL HYDROCHLORIDE
[1S,2S]-(+)-2-[METHYLAMINO]-1-PHENYLPROPAN-1-OL HYDROCHLORIDE
(1S,2S)-2-METHYLAMINO-1-PHENYLPROPANOL HYDROCHLORIDE
(+)-1S,2S-PSEUDOEPHEDRINE HCL
(1S,2S)-(+)-PSEUDOEPHEDRINE HYDROCHLORIDE
D-ISOEPHEDRINE HYDROCHLORIDE
D-PSEUDOEPHEDRINE HYDROCHLORIDE
ISOEPHEDRINE HYDROCHLORIDE
PSEUDOEPHEDRINE HCL
PSEUDOEPHEDRINE HCL, (+)-1S,2S-
(+)-PSEUDOEPHEDRINE HYDROCHLORIDE
PSEUDOEPHEDRINE HYDROCHLORIDE
(+)-PSI-EPHEDRINE HYDROCHLORIDE
PSI-EPHEDRINE HYDROCHLORIDE
a)]-
alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r*,r*))-benzenemethano
benzenemethanol,alpha-[1-(methylamino)ethyl]-,hydrochloride,[s-(theta,thet
hydrochloride,l-(+)-pseudoephedrin
l(+)-pseudoephedrinehydrochloride
novafed | [EINECS(EC#)]
206-462-1 | [Molecular Formula]
C10H16ClNO | [MDL Number]
MFCD00058088 | [Molecular Weight]
201.69 | [MOL File]
345-78-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
185-188 °C(lit.)
| [alpha ]
61 º (c=5, H2O,2dm tube) | [storage temp. ]
Refrigerator (+4°C) | [solubility ]
Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride. | [form ]
neat | [pka]
9.22(at 25℃) | [Merck ]
13,8007 | [BRN ]
3915112 | [Contact allergens]
This sympathomimetic a-adrenergic agonist is found
in plants of the genus Ephedra (Ephedraceae) and is
systemically used as a nasal decongestant. It can induce
drug skin reactions such as acute generalized exanthematic
pustulosis or generalized eczema. | [CAS DataBase Reference]
345-78-8(CAS DataBase Reference) | [EPA Substance Registry System]
345-78-8(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
Non-selective adrenergic agonist; decongestant (nasal).
Controlled precursor. | [Definition]
ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine. | [Brand name]
Efidac (ALZA); Novafed (Sanofi Aventis);
Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert). | [Clinical Use]
Nasal decongestant | [Drug interactions]
Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive
effect of adrenergic neurone blockers.
Anaesthetics: increased risk of ventricular
arrhythmias with isoflurane.
Antibacterials: risk of hypertensive crisis with
linezolid.
Antidepressants: risk of hypertensive crisis with
MAOIs and moclobemide.
Dopaminergics: avoid concomitant use with
selegiline and rasagiline. | [Metabolism]
A small amount of pseudoephedrine is hepatically
metabolised by N-demethylation.
It is excreted largely unchanged in the urine with small
amounts of its hepatic metabolite. | [Purification Methods]
1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.] |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
1544 | [WGK Germany ]
3
| [RTECS ]
UL5950000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29394200 | [Toxicity]
LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles) |
|