| Identification | Back Directory | [Name]
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH | [CAS]
34273-12-6 | [Synonyms]
DRVYIHPFH
Angiotensin A
H2N-DRVYIHPFH-OH
ANGIOTENSIN (1-9)
ANGIOTENSIN I (1-9)
ANGIOTENSIN 1/2 (1-9)
Des-Leu angiotensin I【human】
ALA-ARG-VAL-TYR-ILE-HIS-PRO-PHE
AngiotensinItrifluoroacetate sal
AngiotensinⅠtrifluoroacetate salt
ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS
AngiotensinItrifluoroacetate salt, 98%
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH USP/EP/BP
L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His-OH
Angiotensin I (1-9) trifluoroacetate salt H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH trifluoroacetate salt | [Molecular Formula]
C56H78N16O13 | [MDL Number]
MFCD00167490 | [MOL File]
34273-12-6.mol | [Molecular Weight]
1183.32 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
≥118.3 mg/mL in DMSO; insoluble in EtOH; ≥51 mg/mL in H2O | [form ]
solid | [pka]
2.91±0.10(Predicted) | [Sequence]
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Definition]
ChEBI: Angiotensin (1-9) is a nine amino acid peptide which is formed when angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy terminal leucine from angiotensin I. It is a anti-cardiac hypertrophy agent. It has a role as a human metabolite, a rat metabolite, an antihypertensive agent and a cardioprotective agent. It is a tautomer of an angiotensin (1-9) dizwitterion. | [Biological Activity]
angiotensin i/ii (1-9) is a peptide (asp-arg-val-tyr-ile-his-pro-phe-his) containing the amino acids 1-9 that are converted from angiotensin i/ii peptide.angiotensin i is formed by the action of renin on angiotensinogen, which has 12 amino acids and is an α-2-globulin produced constitutively and released into the circulation mainly by the liver. renin cleaves the peptide bond between the leucine (leu) and valine (val) residues on angiotensinogen, creating the ten-amino acid peptide angiotensin i. angiotensin i is converted to angiotensin ii (aii) through removal of two c-terminal residues by the enzymeangiotensin-converting enzyme (ace), primarily through ace within the lung.angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. angiotensin also stimulates the release of aldosterone, which promotes sodium retention in the distal nephron so that drives blood pressure up.figure1 formula of angiotensin i/ii (1-9) | [References]
1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9. 2. Richard A. Preston. et. (1998). “Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy”. JAMA. 1998;280(13):1168-1172.3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical. |
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