| Identification | Back Directory | [Name]
ANGIOTENSIN III, HUMAN | [CAS]
13602-53-4 | [Synonyms]
RVYIHPF
ANGIOTENSIN III
ANGIOTENSIN III, HUMAN
angiotensin III, 5-Ile-
[DES-ASP1]-ANGIOTENSIN II
ARG-VAL-TYR-ILE-HIS-PRO-PHE
ANGIOTENSIN II HEPTAPEPTIDE
ANGIOTENSIN III ACETATE SALT
ANGIOTENSIN III (HUMAN, MOUSE)
H-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH
ANGIOTENSIN III, HUMAN USP/EP/BP
ANGIOTENSIN III (HUMAN) 2ACOH 4H2O
Angiotensin III, human, mouse(3TFA)
2-8-Angiotensin II, 5-L-isoleucine-
DES-ASP-1-ANGIOTENSIN II ACETATE SALT
ARG-VAL-TYR-ILE-HIS-PRO-PHE 2ACOH 4H2O
ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH CH3COOH 4H2O
Human angiotensin III/Angiotensin III(mouse)
Angiotensin III H-Arg-Val-Tyr-Ile-His-Pro-Phe-OH | [Molecular Formula]
C46H66N12O9 | [MDL Number]
MFCD00167500 | [MOL File]
13602-53-4.mol | [Molecular Weight]
931.09 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
H2O: 1.0 mg/mL, clear, colorless
| [form ]
Lyophilized. | [pka]
3.56±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT1) and AT2 receptors, with a 30-fold higher affinity for AT2 compared with AT1 in HEK293 cells. Ang III is the preferred agonist for renal AT2 receptors, which are responsible for sodium excretion into the urine. Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity in vivo. In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure. | [Uses]
Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively. | [Definition]
ChEBI: Angiotensin III is a peptide. | [in vivo]
Angiotensin III (7, 14 and 28 nmol/kg/min) increases urine sodium excretion (UNaV), fractional excretion of sodium (FENa), and fractional excretion of lithium (FELi) in SD rat[2]. In RAS (renin-angiotensin system), Angiotensin III increases sympathetic nerve activity and vasopressin release and decreases the baroreflex leading to higher blood pressure in rats[3]. | [IC 50]
AT2 Receptor | [storage]
Desiccate at -20°C | [References]
[1] Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. DOI:10.1042/CS20110036
[2] Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95. DOI:10.1161/HYPERTENSIONAHA.112.191403
[3] Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48. DOI:10.1042/CS20130396 |
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