| Identification | Back Directory | [Name]
Bombesin | [CAS]
31362-50-2 | [Synonyms]
BOMBESIN
bombesin acetate
BOMBESIN ACOH 7H2O
Bombesin, Free Base
BOMBESIN ACETATE SALT
PYR-QRLGNQWAVGHLM-NH2
bombesin acetate hydrate
Bombesin acetate salt hydrate
M.W. 1619.85 C71H110N24O18S
Bombesin hydrate acetate salt
2-l-glutamine-6-l-asparagine-alytesi
2-l-glutamine-6-l-asparagine-alytesin
BOMBESIN SYNTHETIC >97% STIMULATES GASTR IN RE
PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2
GLP-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2
PGLU-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2
H-PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2
PYROGLU-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET NH2
PYR-GLN-ARG-LEU-GLY-ASN-GLN-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2 ACOH 7H2O
5-Oxo-L-Pro-L-Gln-L-Arg-L-Leu-Gly-L-Asn-L-Gln-L-Trp-L-Ala-L-Val-Gly-L-His-L-Leu-L-Met-NH2 | [Molecular Formula]
C71H110N24O18S | [MDL Number]
MFCD00167514 | [MOL File]
31362-50-2.mol | [Molecular Weight]
1619.85 |
| Chemical Properties | Back Directory | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
0.05 M acetic acid: 20 mg/mL, clear, colorless
| [form ]
Powder | [pka]
13.04±0.46(Predicted) | [color ]
White to off-white | [optical activity]
-20.624〔DMF-HMPT(8：2)〕 | [Merck ]
13,1320 | [BRN ]
9611365 | [Sequence]
Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
Gut tetradecapeptide with the ability to stimulate release of various hormones | [Biological Activity]
Bombesin/gastrin releasing peptide (BN/GRP) serves as an autocrine growth factor in small cell lung cancer (SCLC). Overexpression of gastrin releasing peptide receptor (GRP-R) is associated with neuroblastoma tumor aggressiveness. GRP-R modulates the important enzymesth at participates in glucose metabolism. Bombesina pulmonary growth factor helps to satisfy the conditions for autocrine stimulation.''Tetradecapeptide originally isolated from the skin of the frog Bombina bombina. Bombesin acts at specific brain nuclei to inhibit food intake. It also increases blood glucose levels. | [storage]
Desiccate at -20°C | [Purification Methods]
Purify Bombesin by gel filtration on a small column of Sephadex G-10 and elute with 0.01 M AcOH. This procedure removes lower molecular weight contaminants which are retarded on the column. The procedure should be repeated twice, and the material should now be homogeneous on electrophoresis, and on chromatography it gives a single active spot which is negative to ninhydrin but positive to Cl2 and iodoplatinate reagents. RF on paper chromatography (n-BuOH/pyridine/AcOH/H2O :: 37.5: 25:7.5:30) is 0.55 for Bombesin and 0.65 for Alytin. [Bernardi et al. Experientia Part 1 27 166 1971, Anastasi et al. Part 2 27 873 1971.] The hydrochloride has m 185o(dec) (from EtOH) [] D -20.6o [c 0.65, Me2NCHO/(Me2N)3PO (8:2)]. [For the stimulation of inositol phosphate see Lloyd et al. Biochem J 260 813 1989.] |
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