| Identification | More | [Name]
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride | [CAS]
30827-99-7 | [Synonyms]
4-(2-AMINOETHYL)-BENZENESULFONYL FLUORIDE
4-(2-AMINOETHYL)BENZENESULFONYLFLUORIDE HCL
4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE
4-(2-AMINOETHYL)BENZENESULPHONYL FLUORIDE HYDROCHLORIDE
4-(2-AMINOETYL)-BENZENESULFONYL FLUORIDE HYDROCHLORIDE
AEBSF
AEBSF HCL
AEBSF HYDROCHLORIDE
PEFABLOC(R) SC
PEFABLOC SC
PEFABLOC SC PLUS
TIMTEC-BB SBB003219
4-(2-AMINOETHYL)BENZENESULFONYLFLUORIDE HYDROCHLOR
Aebsf(4-(2-Aminoethyl)BenzenesulfonylFluoride)Hydrochloride
4-(2-Aminoethyl)Benzenesulphonylfluoridehydrochloride98+%
AEBSF-HCl research grade
Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride
AEBSF HYDROCHLORIDE (4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDE)
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 98+%
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, AEBSF | [EINECS(EC#)]
608-547-2 | [Molecular Formula]
C8H11ClFNO2S | [MDL Number]
MFCD00132962 | [Molecular Weight]
239.69 | [MOL File]
30827-99-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
175-177 °C
| [storage temp. ]
0-6°C | [solubility ]
H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.) | [form ]
Powder | [color ]
White | [PH]
pH3.0～5.0 (10g/L, 25℃) | [Water Solubility ]
10 g/L (20 ºC) | [Sensitive ]
Moisture Sensitive | [BRN ]
7604627 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator | [InChIKey]
WRDABNWSWOHGMS-UHFFFAOYSA-N | [CAS DataBase Reference]
30827-99-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 3261 | [WGK Germany ]
3 | [Hazard Note ]
Corrosive | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29214990 |
| Hazard Information | Back Directory | [Description]
AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins.1 AEBSF can also prevent the activation of the ROS generator, NADPH oxidase.2 At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy.3 AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.1 | [Chemical Properties]
white powder | [Uses]
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation. | [General Description]
Pefabloc? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride. | [Biochem/physiol Actions]
Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM. | [storage]
Desiccate at -20°C | [References]
1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639
2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292 |
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