| Identification | More | [Name]
2-Chlorothiazole | [CAS]
3034-52-4 | [Synonyms]
2-CHLORO-1,3-THIAZOLE
2-CHLOROTHIAZOLE
2-CHLOROTHIOZOLE
2-CHLOTHIOZOLE
2-CHLOROTHIAZOLE, 95+%
1-BENZYLPYRROLIDINE-3-CARBOXYAMIDE | [EINECS(EC#)]
221-228-9 | [Molecular Formula]
C3H2ClNS | [MDL Number]
MFCD00210701 | [Molecular Weight]
119.57 | [MOL File]
3034-52-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
85 °C | [Boiling point ]
145 °C | [density ]
1.378 | [refractive index ]
n20/D1.551 | [Fp ]
54℃ | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
soluble in Ether | [form ]
clear liquid | [pka]
0.84±0.10(Predicted) | [color ]
Colorless to Almost colorless | [InChI]
InChI=1S/C3H2ClNS/c4-3-5-1-2-6-3/h1-2H | [InChIKey]
KLEYVGWAORGTIT-UHFFFAOYSA-N | [SMILES]
S1C=CN=C1Cl | [CAS DataBase Reference]
3034-52-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
1993 | [WGK Germany ]
1 | [HazardClass ]
3 | [PackingGroup ]
Ⅲ | [HS Code ]
2934100090 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow liquid | [Definition]
ChEBI: 2-chlorothiazole is a member of 1,3-thiazoles and an organochlorine compound. | [Reactivity Profile]
Halogen atoms in the 4- and 5-positions of thiazoles exhibit different reactivities depending on the nucleophile: with methoxide ion in methanol the reactivity sequence is 5-chlorothiazole > 2-chlorothiazole > 4-chlorothiazole. In contrast, with thiophenoxide ion or piperidine in methanol, the sequence 2 > 4 > 5 is observed. With the series of alkoxide ions methoxide, ethoxide, isopropoxide and t-butoxide in the corresponding alcohol, the reactivity ratios of 4-chlorothiazole versus 2-chlorothiazole are: 0.07, 0.6, 4, 42. The nucleophilic reactivity of 2-halogenothiazoles is strongly affected by substituents: 2-chloro-5-nitrothiazole is more reactive than 2-chlorothiazole by a factor of 10. |
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