| Identification | Back Directory | [Name]
CB 300919 | [CAS]
289715-28-2 | [Synonyms]
CB 300919
MPI-0479626
CB300919; CB-300919
4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide
4-[[[7-Chloro-3,4-dihydro-3-methyl-2-[(4-methyl-1-piperazinyl)methyl]-4-oxo-6-quinazolinyl]methyl]-2-propyn-1-ylamino]-N-(3-pyridinylmethyl)benzamide
Benzamide, 4-[[[7-chloro-3,4-dihydro-3-methyl-2-[(4-methyl-1-piperazinyl)methyl]-4-oxo-6-quinazolinyl]methyl]-2-propyn-1-ylamino]-N-(3-pyridinylmethyl)- | [Molecular Formula]
C32H34ClN7O2 | [MOL File]
289715-28-2.mol | [Molecular Weight]
584.11 |
| Chemical Properties | Back Directory | [Melting point ]
120℃ | [density ]
1.26 | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [form ]
Powder | [pka]
14.31±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CB 300919 is a quinazoline-based antitumour agent with high activity in the CH1 human ovarian tumour xenograft. CB 300919 has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft[1]. CB 300919 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702. DOI:10.1021/jm011081s |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|