| Identification | More | [Name]
Isoxazole | [CAS]
288-14-2 | [Synonyms]
ISOXAZOLE
1-Oxa-2-azacyclopentadiene
Isooxazole
ISOXAZOLE 98+%
1,2-Oxazole | [EINECS(EC#)]
206-018-7 | [Molecular Formula]
C3H3NO | [MDL Number]
MFCD00003149 | [Molecular Weight]
69.06 | [MOL File]
288-14-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless liquid | [Melting point ]
-67.1°C | [Boiling point ]
93-95 °C(lit.)
| [density ]
1.078 g/mL at 25 °C(lit.)
| [vapor density ]
2.4 (vs air)
| [refractive index ]
n20/D 1.427(lit.)
| [Fp ]
48 °F
| [storage temp. ]
Store at RT. | [solubility ]
167g/l | [form ]
clear liquid | [pka]
-2.0(at 25℃) | [color ]
Colorless to Light yellow | [BRN ]
103773 | [InChIKey]
CTAPFRYPJLPFDF-UHFFFAOYSA-N | [Uses]
Natural insecticide. | [CAS DataBase Reference]
288-14-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Isoxazole(288-14-2) | [EPA Substance Registry System]
288-14-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,Xi | [Risk Statements ]
R11:Highly Flammable. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S33:Take precautionary measures against static discharges .
S29:Do not empty into drains .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 1993 3/PG 2
| [WGK Germany ]
3
| [F ]
10 | [Hazard Note ]
Highly Flammable | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Description]
Isoxazole(288-14-2), an important class of heterocycles, is a five membered heterocyclic compound that exhibits various pharmacological actions. It is present in some natural products such as ibotenic acid and is also used as a foundation for several drugs such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs. Isoxazoles are largely applied in the area of pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumour, antifungal, antituberculosis, anticancer and ulcerogenic. Besides, it has a great effect on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, controlling and reducing the risk of HIV.
| [Chemical Properties]
A colorless liquid resembling pyridine. It is soluble in water at room temperature up to six times its volume. | [Definition]
ChEBI: A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles. | [Preparation]
Isoxazoles can be synthesized by various methods, such as the 1,3-dipolar cycloaddition reaction of nitrile oxides with alkynes, the reaction of hydroxylamine with 1,3-diketones or propiolic acid derivatives, etc. | [General Description]
Isoxazole are described as inhibitors of acetylcholinesterase (AChE). Isoxazole ligands bind to and inhibit the Sxc- antiporter. | [Hazard]
Narcotic and psychomimetic effects. | [References]
https://en.wikipedia.org/wiki/Isoxazole
https://pubchem.ncbi.nlm.nih.gov/compound/9254 |
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