| Identification | Back Directory | [Name]
LE 300 | [CAS]
274694-98-3 | [Synonyms]
LE 300
6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f]benzazecine
7-METHYL-6,7,8,9,14,15-HEXAHYDRO-5H-BENZ[D]INDOLO[2,3-G]AZECINE
6,7,8,9,14,15-HEXAHYDRO-7-METHYL-5H-INDOLO[3,2-F][3]BENZAZECINE
5H-Indolo[3,2-f][3]benzazecine, 6,7,8,9,14,15-hexahydro-7-methyl- | [Molecular Formula]
C20H22N2 | [MDL Number]
MFCD00951284 | [MOL File]
274694-98-3.mol | [Molecular Weight]
290.4 |
| Chemical Properties | Back Directory | [Melting point ]
>91°C (dec.) | [storage temp. ]
Store at RT | [solubility ]
DMSO: 26 mg/mL | [form ]
solid | [color ]
Off-White to Pale Beige | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg). | [Uses]
LE 300 is a potent and selective dopamine receptor antagonist. | [Definition]
ChEBI: LSM-2007 is a member of indoles. | [Biological Activity]
Potent and selective dopamine D 1 receptor antagonist (K i values are 0.08-1.9 nM and 6-45 nM for D 1 and D 2 receptors respectively). Also displays moderate affinity for the 5-HT 2A receptor (K i = 20 nM). Active in vivo . | [storage]
Room temperature |
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| Company Name: |
BOC Sciences
|
| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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